Y. Feng

The paper reports cryo-EM structures of cyanobacterial transcription initiation complexes and identifies an SI3-{sigma} arch that stabilizes the RNAP-promoter DNA open complex, essential for transcription initiation.

This study identifies NR2F6 as a melanoma-intrinsic regulator of anti-tumor immunity, showing that its inhibition enhances immunotherapy response and tumor suppression.

This study uses RNA-seq to identify molecular changes in kidney cancer among people living with HIV, finding altered expression of specific genes and pathways associated with cancer progression.

The paper describes a high-throughput method to screen V-ATPase inhibitors/activators using Acridine Orange in yeast vacuoles.

This paper designs and characterizes bispecific antibodies effective against multiple SARS-CoV-2 Omicron sublineages and determines their cryo-EM structures.

This paper develops a lab-on-a-chip method for analyzing biomolecular processes with high sensitivity and single molecule resolution in physiological conditions.

This study investigates how mental health interventions affect Alzheimer's disease progression through immune mechanisms in transgenic mice.

The paper uses long-term experimental data to test hypotheses about plant diversity loss under nutrient enrichment, finding support for competitive asymmetry and soil acidification over niche dimension.

This study maps lactylation sites in Toxoplasma gondii and identifies its role in gene regulation and metabolic processes.

This study compares genome rearrangement features across ciliates to understand the evolutionary origin of massively scrambled genomes.

This study shows that CTRP3 reduces intestinal inflammation in colitis models and IBD patients by modulating SIRT1/NF-κB signaling to suppress pro-inflammatory cytokines.

This study identifies Slamf9+Spp1+ macrophages in hamsters that promote SARS-CoV-2 clearance and inflammation resolution through spatial transcriptomics and scRNA-seq.

This paper identifies CRISPR-Cas immunity in Trichodesmium thiebautii as a factor contributing to its numerical dominance over T. erythraeum in oceanic nitrogen fixation.

This study shows bumblebees use only ordinal memory of foraging options, not absolute reward values, when making decisions in novel pairings.

This study evaluates the effectiveness of WT and variant-specific mRNA vaccines against SARS-CoV-2 Omicron BA.2 subvariant using vaccinated serum from animals.

This study shows that an adjuvanted subunit vaccine provides durable protection against SARS-CoV-2 Omicron in non-human primates, with strong neutralizing antibodies and memory T/B cells after booster doses.

This paper develops a novel murine model of mania through environmental stressors and validates it against depression models and controls.

This paper introduces a method to create autonomously regulated oxygen microenvironments in microscale cell cultures using an oil overlay, validated with simulations and experiments across multiple cell types.

This study examines the bladder microbiome, metabolome, and cytokines in SLE patients, finding associations between microbial composition and disease-related metabolites and cytokines.

This study shows Hantaan virus uses mitochondrial OXPHOS for replication, driven by AKT activation and PNPT phosphorylation.

This study identifies Siah1/2 as E3 ligases that degrade dissociated CycT1 in resting cells, preventing P-TEFb formation.

This study shows that ALA-PDT kills drug-resistant M. marinum in vitro and in a mouse model, leading to recovery of cutaneous lesions and clinical improvement in two patients.

This study shows boron alleviates aluminum toxicity in Arabidopsis roots by restoring PIN2 endocytosis and auxin transport, reversing auxin depletion in the elongation zone.

This study extracts and purifies β-2,7,11-cembratriene-4,6-diol from tobacco leaves and demonstrates its antiviral activity against TMV through in vivo and molecular assays.

This study shows that DNMT3A mutations impair replication fork recovery, leading to DNA damage and sensitivity to nucleoside analogs like cytarabine.

This study identifies melanoma addiction to GCDH, showing that GCDH controls NRF2 glutarylation, which limits apoptotic UPR signaling and tumor growth.

This study identifies shared hotspot mutations in canine and human cancers, highlighting dogs as a valuable model for precision cancer therapeutics.

The paper models aerosol particle transport through lung mucus using computational fluid dynamics to predict penetration and distribution, considering mucus properties and particle interactions.

The paper identifies TAZ as a molecular switch driving phenotypic transition and metastasis in SCLC by analyzing mouse models and human data.