Y. Han

This study identifies a chitin-binding protein, CgCBP, highly expressed in the outer fold of the mantle of Pacific oyster Crassostrea gigas, which is linked to shell pigmentation through its role in periostracum structure.

This study identifies and characterizes DacM, a diadenylate cyclase in Mycoplasma ovipneumoniae that produces c-di-AMP, and presents its crystal structures to inform drug design.

This study shows cohesin mutations enhance cancer cell sensitivity to anti-PD-1 therapy by increasing PD-L1 through endogenous retrovirus activation.

This study examines the bioaccumulation and immune response of sea cucumbers exposed to chronic dietary hexavalent chromium, finding tissue-specific accumulation and altered enzyme activities.

This study identifies novel viral genomic components and evolutionary patterns using conserved untranslated regions (UTRs) and UTR-backed iterative BLASTn in multipartite viruses.

This study compares the effects of Cr(III) and Cr(VI) stress on Arabidopsis thaliana, showing Cr(VI) is more toxic due to greater growth inhibition, oxidative stress, and chloroplast damage.

This study examines how nicotine and estrogen affect articular cartilage friction and PRG4 secretion in vitro, finding nicotine reduces friction and PRG4 while estrogen reverses these effects.

This study evaluates the metastatic abilities of HER2-positive breast cancer cell lines in xenograft models and identifies gene signatures associated with metastatic preferences.

This study uses first-principles calculations to show rutile TiO2 (110) nanosheets have strong adsorption for DNA nucleobases, exceeding graphene by over 20 times, with implications for DNA sensors and sequencers.

This study uses smFRET to show SARS-CoV-2 variants have more open Spike conformations and slower transitions, increasing their stability and transmission efficiency.

This study identifies and characterizes Aeromonas species in farmed loaches from China, finding high prevalence of A. veronii and resistance to multiple antibiotics.

The paper introduces a terrain treadmill to study animal locomotion through large obstacles over large spatiotemporal scales with high-resolution observations.

The paper investigates how stress granules interact with microtubules in human cells, finding non-specific adhesive forces that influence droplet deformation and network structure.

The paper shows that ECM dimensionality affects actin tension, which in turn modulates endoplasmic reticulum function and spheroid resilience in mammary epithelial cells.

The paper presents the cryo-EM structure of TMEM120A, revealing it binds coenzyme A and shares structural features with ELOVL fatty acid elongase, suggesting a potential role in fatty acid metabolism rather than mechanosensation.

The paper identifies transcriptomic signatures in aging striated muscle that predict protein level changes and prioritizes genes with age-dependent expression in humans.

The paper identifies the PATAN domain of PatA-type regulators as the key domain interacting with the Type IV pilus motor to control phototactic orientation in Synechocystis.

This study identifies pUL21 as a viral phosphatase adaptor that promotes HSV-1 replication and spread by directing dephosphorylation and antagonizing pUS3 kinase activity.

This paper describes an engineered contact lens that passively releases lifitegrast for up to 10 hours, achieving therapeutic concentrations to treat dry eye syndrome.

This study identifies falcilysin as a target of anti-malaria drugs and reveals a shared inhibitory pocket that could guide new drug development.

Overexpression of VDAL in Arabidopsis enhances resistance to Verticillium dahliae by preventing degradation of the transcription factor MYB6 through interaction with PUB25/26 E3 ligases.

ZF2001, a tandem-repeat dimeric RBD protein vaccine, induces strong immune responses and protects mice and non-human primates from SARS-CoV-2 infection.

This study evaluates a recombinant chimpanzee adenovirus vaccine expressing a dimeric tandem-repeat RBD of SARS-CoV-2, showing enhanced immune responses and protection in mice.

This paper develops an all-solid-state heterojunction oxide transistor for rapid, real-time detection of biomolecules and SARS-CoV-2 spike S1 protein at attomolar concentrations.

This study compares the performance of Autof MS 1000 and Bruker MALDI-TOF MS systems in identifying Nocardia species using clinical isolates and sequence analysis as a reference.

This paper introduces a hierarchical 3D-motion learning framework to map animal spontaneous behavior by capturing kinematics and learning dynamic behavior patterns.

The paper reports the crystal structure of PbSRD5A and provides biochemical insights into the conserved mechanism of steroid 5-reductase catalysis.

This study identifies antiviral compounds that reduce SARS-CoV-2 viral load by counteracting the virus-induced transcriptional landscape, without affecting viral entry or host antiviral response.

This study presents EM structures of the human mitochondrial calcium uniporter holocomplex with and without Ca2+, showing how Ca2+ affects its assembly and channel pore blockage.

This study identifies proteomic changes in mouse hearts after paraquat exposure, showing mitochondrial dysfunction and antioxidant activation, with limited overlap with lung responses.