Y. Hu

This paper identifies a potent SARS-CoV-2 antibody, 553-49, that neutralizes the Omicron variant by targeting a conserved epitope and disassembling spike trimers.

The paper uses single-cell RNA sequencing to identify novel cell subsets in subchondral bone of OA patients and elucidates their roles in disease progression.

This study identifies climate-driven factors shaping nematode diversity in forest soils across different climatic zones.

This study identifies a unique epithelial cell population in human distal airways and shows its reduction in COPD, linked to IFN-gamma signaling.

This study develops a chimeric mRNA vaccine that provides broad protection against Omicron and Delta variants of SARS-CoV-2 by combining RBDs from different variants.

This study identifies mutations in SARS-CoV-2 variant B.1.1.7 that reduce HLA-A2 restricted CD8+ T cell epitope binding and impair cellular immune responses.

LabGym quantifies user-defined animal behaviors using a learning-based approach, providing holistic assessment without pre-defined features or species restrictions.

This paper develops lyophilized mRNA-lipid nanoparticle vaccines that maintain stability at room temperature and show high antigenicity against SARS-CoV-2 variants in preclinical and human trials.

This study shows that knocking out OsSWEET15 in rice reduces fertility by impairing embryo formation and seed-setting, with similar effects observed in OsSWEET11 mutants.

This study examines the P132H mutation in Omicron SARS-CoV-2 Mpro, finding it reduces thermal stability without affecting catalytic activity or drug inhibition.

This study examines how reactive oxygen species-induced protein carbonylation reduces wheat seed vigor during aging by correlating carbonyl protein content with seed vitality and structural changes.

This paper develops a genetic strategy in Arabidopsis thaliana to replace histone H4 with mutants, identifies H4R17 as a regulator of flowering time via ISWI complex interaction, and provides a resource for studying histone function.

The paper determines the asymmetric homodimer structure of mouse pendrin using cryo-EM, revealing its electroneutral anion exchange mechanism and pathogenetic mutation properties.

This study shows that horizontal gene transfer created momilactone biosynthetic gene clusters in grasses, with subsequent gene recruitment and loss shaping their evolution.

Antibodies from 3-dose vaccinated individuals neutralize Omicron and other variants, with some being ultrapotent and broadly reactive.

This study shows that quetiapine exposure increases antibiotic resistance in E. coli by inducing marR mutations and altering gene expression.

This study develops a 3D in vitro model of the device-tissue interface to show that antioxidant ceria nanoparticles reduce oxidative stress and neuroinflammation.

This study shows brilacidin has broad-spectrum antiviral activity against multiple human coronaviruses by targeting both the virus and host cell heparan sulfate proteoglycans.

ReCOV, a trimeric SARS-CoV-2 subunit vaccine, induced neutralizing antibodies and complete protection against SARS-CoV-2 in mice and rhesus macaques.

The paper identifies an ultrathin calcified region in human knee osteochondral interface tissue with two-layered micro-nano structures and exponential modulus increase, enhancing energy dissipation and fatigue resistance.

This study shows that GH3 amido synthetases conjugate auxin, and their deletion causes developmental defects in Arabidopsis roots and flowers.

This study identifies integrin mechanotransduction as essential for directing cytotoxic secretion at the immune synapse, showing that mechanical forces from LFA-1 guide lytic granule fusion and cytotoxicity.

This study uses single-cell RNA sequencing to analyze immune cell changes during glioma progression, identifying immunosuppressive myeloid cell subsets and potential therapeutic targets.

This study identifies ELMOD1 and ELMOD3 as regulators of ciliogenesis and ciliary protein traffic, with phenotypes similar to ELMOD2 deletion but distinct in their effects on Golgi-ciliary transport.

This study compares the metabolic capabilities of gut symbionts in turtle ant larvae and adults, revealing functional overlap despite taxonomic divergence.

This study identifies pD345L as an ASFV protein that inhibits NF-κB signaling by blocking IKK kinase activity, providing insights into ASFV immune evasion mechanisms.

The paper identifies GPR87 as a novel marker for KRT5+ basal cells in IPF distal bronchioles and honeycomb cysts using single-cell RNA sequencing.

This study identifies Vinigrol as a broad-spectrum anti-cancer agent that activates the PERK/eIF2 arm of the UPR via ATF4/DDIT3 to induce breast cancer cell death.