Y. Hu

The paper establishes a bacterial genome and culture collection of the piglet gut microbiome, revealing new species and functional insights.

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

This study identifies potent SARS-CoV-2 PLpro inhibitors through high-throughput screening and a FlipGFP-based assay, showing improved antiviral activity compared to existing compounds.

This study shows that RANKL from bone marrow adipocytes regulates trabecular osteoclast formation and bone loss in mice, with implications for therapeutic targeting of bone marrow adiposity.

This study shows that daily administration of LuCI, an oral gut coating agent, leads to weight loss and improved insulin sensitivity in a rat model of diet-induced obesity.

This study examines immune cell profiles in COVID-19 survivors with and without pulmonary sequelae one year post-discharge, identifying immune imbalances linked to residual lung damage.

This study identifies PPP1R14C as a driver of triple-negative breast cancer progression by inactivating GSK3β through PP1 inhibition and TRIM25-mediated degradation of non-phosphorylated GSK3β.

This study identifies direct kinase targets of Compound Danshen Dropping Pills using literature, public databases, and in silico models, finding 30 targets at 25 g/ml and 9 dose-dependent targets at 250 g/ml.

The paper develops a mathematical model to show that host-pathogen interactions can lead to bistable infection outcomes, where pathogen load either proliferates or is eliminated.

This study shows that the QpH1 plasmid in Coxiella burnetii is essential for colonizing murine macrophages and highlights its role in the bacterium's persistence in rodents.

This study identifies ZmLBD5 and ZmLBD33 as class II LBD genes in maize that regulate gibberellin and abscisic acid biosynthesis, affecting plant growth and drought tolerance.

The paper shows women are more protected from aggressive cutaneous squamous cell carcinoma due to stronger immune activation compared to men.

This study evaluates glycoproteomics software performance using human serum datasets, identifies high-performance strategies, and provides recommendations for improved analysis.

This study links genomic changes like WGD and gene duplication to phenotypic innovation and diversification in gymnosperms, showing ecological factors also drive diversification after angiosperms.

This study shows that elaborated feedback during instructor-learner interactions enhances learning transfer and is associated with neural synchronization in frontoparietal regions.

This study identifies age-associated clonal B cells (ACBCs) as drivers of B-cell lymphoma in mice, linking aging-related epigenetic and cellular changes to cancer development and proposing mTOR/c-Myc inhibition as a therapeutic strategy.

This study identifies age and ethnicity-specific gene expression biomarkers for immune aging using transcriptomic data from peripheral blood mononuclear cells.

This study uses NMR to show that the PAM LY2119620 changes the structure and dynamics of M2R in both extracellular and G-protein coupling domains, stabilizing distinct conformations not seen with orthosteric agonists.

The paper identifies synergistic genetic targets in Ph-like B-ALL using network analysis to guide combination therapy, showing improved efficacy in preclinical models.

This study identifies multiple HIV-1 escape mechanisms from PGT135 in a slow progressor, highlighting the role of glycan sites and V1/V4/C2 region changes in antibody resistance.

This study designs non-covalent SARS-CoV-2 Mpro inhibitors using structure-based design and Ugi-4CR reactions, identifying 23R as the most potent compound with antiviral activity.

The paper develops a novel isothermal amplification method (LMCP) for detecting Oryza sativa ITS with higher sensitivity and speed compared to LAMP.

This study determines the structure of SARS-CoV-2 Mpro with calpain inhibitors and analogues, revealing new insights for developing dual inhibitors against Mpro and cathepsin L.

This study shows TEAD4 and PKM2 are upregulated in LUAD and linked to poor prognosis, with TEAD4 promoting PKM2 transcription and glycolysis, suggesting targeting this axis could be a therapeutic strategy.

This study identifies four compounds with broad-spectrum antiviral activity against multiple coronaviruses, including SARS-CoV-2, by inhibiting viral Mpro and cathepsin L.

This study investigates the role of WRKY31 and signaling compounds in enhancing insect resistance in Pinus massoniana L. against Dendrolimus punctatus by modulating hormone signaling pathways.

This study identifies CDF-1 and SUR-7 as regulators of lipid metabolism in C. elegans, linking zinc homeostasis to lipid accumulation via the SREBP-SCD pathway.

This study uses proteomics to identify down-regulated ECM proteins in guinea pig cochleae after noise exposure, linking them to hearing loss mechanisms.

This study shows that CISH knockout in TIL enhances neoantigen reactivity and synergizes with PD1 blockade to improve tumor regression.

This study shows that six compounds inhibit SARS-CoV-2 Mpro non-specifically and their antiviral activity cannot be predicted by IC50 values in the absence of DTT.