Z. Zhu

This study visualizes fungal nutrient acquisition and transport through mineral interfaces in a soil micromodel, revealing mechanosensory responses and specific transport mechanisms.

This study identifies the Y453F mutation in SARS-CoV-2 spike protein as enhancing binding to mink ACE2 while maintaining human ACE2 utilization, highlighting its role in host adaptation.

This study shows GC-derived exosomes induce EMT in peritoneal mesothelial cells via TGF-β1/Smads pathway, enhancing GC cell migration and adhesion.

This study shows that exosomal miR-328 from lung adenocarcinoma cells promotes osteoclastogenesis by targeting Nrp2 and suggests its inhibitors as a potential treatment for bone metastasis.

ASER compiles sex reversal data from 18 species, including genes, regulatory networks, RNA-seq, and ISH images, to support research on animal breeding and human health.

This study identifies genes with allele-specific expression in glioblastoma stem cells, finding SLFN11 loss linked to drug resistance and susceptibility to Zika virus.

This study shows that the N protein mutations R203K/G204R increase SARS-CoV-2 infectivity, replication, and virulence, contributing to its spread and disease severity.

The paper shows lung epithelial cells can produce TD-Ag-specific antibodies, dependent on CD4+ T cells, challenging the notion that B cells are the sole source of such antibodies.

The paper investigates syncytia formation between SARS-CoV-2 infected and ACE2-expressing cells, finding that it leads to pyroptosis via Caspase-9 and GSDME activation, contributing to severe COVID-19 inflammation.

This study identifies DARPP-32 as a mediator of ERBB3-driven resistance to EGFR TKIs in lung adenocarcinoma, showing its role in promoting oncogenic signaling and tumor progression.

This study identifies a small molecule that stabilizes Z α1-antitrypsin, reduces polymerization, and increases its secretion in cells and mice.

This study measures how changes in intraocular and intracranial pressure affect the optic nerve head in monkeys using OCT, showing significant interactions between the pressures.

This study shows that 1 μM Dexmedetomidine reduces H9C2 cardiomyocyte injury under hypoxia/reoxygenation by partially inhibiting endoplasmic reticulum stress.

This study shows that Top1 inhibition with Topotecan reduces SARS-CoV-2-induced inflammation and mortality in animal models.

This study identifies genetic factors enabling Exiguobacterium's cosmopolitan distribution through comparative genomics and metabolic analysis of 103 strains.

This study shows metformin reduces high glucose-induced endothelial ROS through the AMPKα-Lin-28-OGG1 pathway in HUVECs and diabetic mice.

This study shows ELF3 is essential for temperature entrainment of the circadian clock in Arabidopsis, affecting thermoresponsive physiological processes.

The paper shows that MYB31 activation and CBG expression in the pericarp of C. chinense leads to high capsaicinoid accumulation, explaining the extreme pungency of these peppers.

The paper identifies lysine isobutyrylation as a new histone modification mark and shows its role in epigenetic regulation and cellular physiology.

The paper reveals conserved interaction rules between RNA helicases and TRIM E3 ligases in vertebrate innate immunity using cryo-EM and biochemistry.

The paper shows that KDM3A and KDM3B, along with OCT4/SOX2, regulate H3K9 methylation to maintain pluripotency in porcine-induced pluripotent stem cells.

The paper identifies low-molecular-weight drugs that inhibit SARS-CoV-2 main protease using a fragment-based approach, finding niacin and hit 1 bind to the catalytic pocket and leading to the discovery of four drug candidates.

This study identifies SARS-CoV-2 host targets and perturbed proteins in PBMCs from COVID-19 patients, revealing potential virulence factors involved in cytokine storms and disease pathogenesis.

The paper develops a sandwich ELISA method using monoclonal antibodies to detect pre-proinsulin in recombinant human insulin production.

This paper presents full-length transcriptome data of Ascosphaera apis mycelium and spore using PacBio SMRT sequencing, providing high-quality transcripts for genome and transcriptome annotation improvements.

This study shows rottlerin reduces DSS-induced colitis in mice by enhancing intestinal barrier function through the Epac-2/Rap-1 signaling pathway.

The paper uses single-cell RNA sequencing to analyze stomatal lineage cell development in Arabidopsis, identifying new marker genes and transcriptional networks.

This study isolates lymphovascular breast cancer cells using LCM and G&T-seq to identify three distinct clonal pathways associated with different survival outcomes and ribosomal protein downregulation as a poor prognosis marker.

The paper predicts nelfinavir as a potential inhibitor of 2019-nCov main protease using homology modeling, molecular docking, and binding free energy calculations.

The paper improves ecological network inference by combining prior knowledge with an ensemble of population dynamics models, showing strong interactions and future trends in a freshwater fish community.