H. Li

This paper introduces SACD, a super-resolution imaging method that reduces acquisition time and improves resolution, enabling high-throughput and 4D live-cell imaging.

This study develops a proteomic strategy to identify chemical probes that perturb protein complexes in human cells by analyzing electrophilic compounds' effects on protein interactions.

This paper adapts a transmitted/founder SHIV to enhance replication in rhesus macaques while preserving HIV-1 Env biology, resulting in a more fit virus for NHP HIV studies.

This paper discovers a new type of Accumulibacter (Type III) with unique functional features and investigates transcriptional and morphological differences among co-occurring strains in wastewater treatment systems.

This study shows chemotherapy-induced reactive myelopoiesis and FX-expressing macrophages promote cancer lung metastasis through CCL2/CCR2 axis and coagulation-inflammation interplay.

This paper introduces a method to quantitatively map the local quality of super-resolution microscopy images, enabling better integration of reconstructions and detection of uncertainties.

This study creates a human fetal cerebellar cell atlas to identify transitional progenitors linked to aggressive medulloblastoma subgroups and their oncogenic mechanisms.

This study identifies that antifungal drug tolerance and resistance in Candida albicans emerge at different drug concentrations and are associated with distinct aneuploid chromosomes.

The paper reports that some data could not be replicated and the manuscript was withdrawn, with parts of the data published elsewhere.

The paper identifies multiple transcription factor perturbations that rejuvenate aged human skin fibroblasts through a Perturb-seq screen and validation of aging hallmarks.

This paper conducts a bibliometric analysis of immunotherapy research in pancreatic cancer, identifying key trends, hotspots, and future directions.

This paper determines the dimer and tetramer structures of human UBR5, revealing its oligomerization mechanism and functional implications for cancer.

The paper uses computational simulations to study how cell mechanics regulate isotropic collagen matrix modeling at large spatial scales, revealing key cellular mechanisms involved.

This study shows SARS-CoV-2 uses actin-rich filopodia for efficient viral entry, revealing two modes of entry and identifying potential antiviral targets.

This study identifies a new class of V2-directed cross-neutralizing antibodies targeting a cryptic epitope in occluded-open HIV and SIV Env trimers.

The paper identifies a circulatory pathway for interstitial fluid flow along vasculature adventitia in rats, regulated by heartbeat and respiration.

This study develops an oral nanoparticle delivery system for metformin in ADPKD, showing improved kidney targeting and bioavailability compared to conventional methods.

A protease inhibitor from kumquat enhances freezing tolerance by stabilizing proteins through inhibition of non-specific protease degradation.

This paper develops and tests a CD46-targeted alpha radioimmunotherapy, 212Pb-TCMC-YS5, showing potent tumor growth inhibition and survival improvement in multiple prostate cancer models.

This study identifies how avian-origin H3N2 influenza viruses adapt to dogs, acquiring traits that increase their potential to infect humans.

This study links SARS-CoV-2 spike-induced syncytia to cellular senescence and exacerbated heart failure, showing that senolytic drugs and WNK1 inhibitors can mitigate cardiac damage.

This study reports cryo-EM structures of all human dopamine receptor subtypes bound to Rotigotine, revealing binding modes, activation mechanisms, and G-protein coupling specificity for drug design.

This study identifies molecular and genetic mechanisms underlying the transition from dioecy to monoecy in Diospyros oleifera using genome-wide analyses of 150 accessions.

This study investigates how excretory-secretory products from Echinococcus granulosus protoscoleces affect mouse hepatocyte growth, function, and glucose metabolism, finding inhibition of proliferation, promotion of apoptosis, and disruption of metabolic pathways.

The paper tests defensin-derived peptides for antifungal activity, finding a peptide with multiple modes of action that shows promise as a bioinspired fungicide.

The paper analyzes Salmonella enterica isolates to show Euramerica's role in global Salmonella spread through pork trade and antimicrobial impact on its evolution.

This study identifies ZNF251 haploinsufficiency as a mechanism conferring PARP inhibitor resistance in BRCA1-mutated cancer cells through RAD51-mediated homologous recombination.

This study shows that simvastatin reduces YAP/TAZ activity and ECM dysfunction in glucocorticoid-treated human trabecular meshwork cells.

The paper traces the evolutionary origin of brackish archaea, showing gene rearrangements enabled their adaptation to coastal environments after the Cryogenian Snowball Earth.

This study shows RGA1 improves pollen tube growth under low-light by enhancing sugar and energy metabolism in rice pistils.