H. Li

This study identifies TRIP6 and LATS1 as novel components of the tension sensor complex at bicellular and tricellular junctions, revealing their distinct distribution and dynamics compared to α-catenin/vinculin.

This paper introduces LSAqp1, a genetically encoded MRI reporter that enables drug-gated, background-free, and multiplex imaging of gene expression in living organisms.

This study introduces VenomSeq, a platform that uses transcriptomics and differential gene expression to link venoms to drugs and diseases, generating new therapeutic hypotheses.

This study combines computational modeling and experiments to show that hypoxia and RBC aggregation enhance macrophage retention of sickle RBCs, contributing to splenic congestion in SCD.

The paper compares co-evolutionary lineages of gut microbes in wild primates and humans, revealing opposing health implications of specific microbial traits.

This study investigates the roles of LPS glycosyltransferases in H. pylori morphology, cell wall permeability, and antimicrobial susceptibility, finding that their deletion alters morphology and increases susceptibility to certain antimicrobials.

This study shows pancreatic tumors co-evolve with retrotransposons to modulate immune responses by regulating viral mimicry through SINEs and L1 retrotransposition.

This paper shows that a bispecific antibody targeting PD-L1 and TIGIT enhances T-cell response and tumor control compared to using the individual antibodies.

This paper introduces SpecGAN, a deep learning method that significantly improves single-molecule spectrum imaging efficiency by reducing photon requirements and increasing temporal resolution.

The paper identifies a modular (L)WY-LWY motif in Phytophthora effectors that recruits host PP2A phosphatase, enabling phosphoprotein regulation through structural mimicry.

This study uses cryo-EM to analyze the structural dynamics of yeast Pol α-primase during primer synthesis, revealing how RNA primers are transferred to DNA polymerase and how primer length is regulated.

This study reports cryo-EM structures of T4 bacteriophage primosome assembly intermediates, revealing how the helicase and primase interact and synthesize RNA primers.

This paper reports high-resolution structures of Rad24-RFC loading 9-1-1 onto DNA gaps, showing preference for ssDNA gaps and revealing a unique mechanism for clamp loading and DNA repair.

The paper shows that salt stress modulates lateral root development through an auxin-independent pathway involving ZAT6 and LBD16.

This study shows nano-silver inhibits and forskolin promotes rice seed germination through regulation of OsPIP2-1 and α-amylase.

This study uses machine learning to predict neoadjuvant chemotherapy response in triple-negative breast cancer by combining histological and molecular biomarkers.

This study shows that Myostatin gene deletion in pigs alters gut microbiota, increasing SCFAs which stimulate fast-twitch glycolytic muscle growth through the Akt/mTOR pathway.

This paper characterizes mitotic phenotypes caused by a MYC synthetic lethal compound, dimethylfasudil, showing cell cycle arrest, mitotic catastrophe, and segregation anomalies.

This study identifies Vangl2 as a negative regulator of NF-κB signaling in sepsis by promoting autophagic degradation of p65 through NDP52.

This study shows that RNA deadenylation by the CCR4-NOT complex is critical for suppressing transposable elements in Arabidopsis, independent of small RNA targeting.

The paper identifies widespread stop codon readthrough events in plants and reveals the plasticity of stop codons in encoding amino acids.

This study identifies RAY1216, a slow-tight SARS-CoV-2 Mpro inhibitor with improved pharmacokinetics and antiviral activity compared to PF-07321332, currently in phase III clinical trials.

The paper shows that evolution in Pseudomonas aeruginosa populations selects for cheater mutants that modify social cooperation to stabilize chronic infections and reduce host immune response.

This paper introduces a new optoretinography technique that detects light-evoked deformations in multiple retinal structures, including rods, pigment epithelium, and subretinal space, with high sensitivity and spatial resolution.

This paper identifies microbiome features distinguishing three patient clusters with abnormal glycometabolism, stratified using unsupervised clustering of clinical parameters.

This study identifies FLZ13 as an ABI5-interacting protein that co-represses growth-related genes to delay seed germination in response to ABA.

This study examines age-related changes in the gut microbiota of captive giant pandas using 16S rRNA sequencing, revealing differences in composition, abundance, and diversity across four age groups.

The paper describes a method for long-term cryopreservation and recovery of hookworms and other gastrointestinal nematodes, enabling better laboratory research and global health applications.

This paper identifies LXY18, a 4-phenoxy-quinoline compound that blocks AURKB relocalization, showing potent antimitotic activity and oral bioavailability.

This study uses single-cell RNA sequencing to identify novel subtypes and intratumoral heterogeneity in olfactory neuroblastoma.