H. Zhang

This study identifies two unique myeloid-derived suppressor cell populations in glioblastoma that promote tumor growth and immune evasion.

The paper evaluates deep learning methods for molecular conformation generation by comparing them to a stochastic 'infinite physical monkey' approach, finding that the monkey method outperforms most DL-based methods in coverage and docking success.

The paper examines mitogenomic evolutionary rates in Bilateria, finding that parasitism and reduced locomotory capacity are associated with elevated rates, explaining a significant portion of variance in branch lengths.

This study shows that excessive apoptosis in naïve T cells causes hyperactivation and accelerates aging in mice, suggesting T-cell changes are a cause of aging.

This study investigates microRNA-195-3p's role in hypoxia-induced injury of human umbilical vein endothelial cells, finding it upregulated and protective against hypoxia.

This study identifies a cleaved form of METTL3, METTL3a, which enhances METTL3-WTAP interaction and promotes breast cancer progression through m6A methylation and mTOR activation.

This study identifies GmAlfin09 as a transcription factor that enhances ER stress resistance in soybean by upregulating GmPRDX6, which reduces ROS levels and maintains ER homeostasis.

The paper introduces DBSN, a deep learning method that enables imaging of multiple subcellular structures using only two fluorescent labels, overcoming spectral overlap limitations.

The paper identifies a methylation-phosphorylation switch regulating EZH2 stability and hematopoiesis through AKT-mediated phosphorylation of EZH2.

This study shows homocysteine increases hepatocyte autophagy by upregulating TFEB through DNMT3b-mediated DNA hypomethylation of the TFEB promoter.

This paper introduces a fast bioorthogonal reaction system for in-cell spin-labeling and DEER spectroscopy, enabling structural studies of proteins in live mammalian cells.

SynBa improves drug combination synergy estimation with uncertainty quantification, enhancing accuracy and reliability for decision-making.

This study shows that SLC7A5 regulates Paneth cell function, affecting intestinal inflammation and cell proliferation through mTORC1 signaling.

This study uses single-cell RNA sequencing to identify novel subtypes and intratumoral heterogeneity in olfactory neuroblastoma.

This study identifies the mechanisms of Schisandrin B in treating diabetic nephropathy using network pharmacology and quantitative proteomics in rats.

This study examines how nitrogen niche partitioning between tropical legumes and grasses affects over-yielding under elevated CO2, finding that niche partitioning and over-yielding decrease in mixtures under higher CO2.

This study shows that reduced Prolyl oligopeptidase (POP) and its product Ac-SDKP contribute to ovarian fibrosis in PCOS mice by altering MMP-2 and TGF-β1 expression.

This study identifies VHL mutation as a driver of CE accumulation in ccRCC through the PI3K/AKT pathway, showing that inhibiting cholesterol esterification suppresses tumor aggressiveness.

This study identifies E166V as a key mutation conferring high nirmatrelvir resistance in SARS-CoV-2, with differential effects on Omicron and WA1 variants, and explores strategies to overcome resistance.

This study identifies WDFY3 as a novel regulator of macrophage efferocytosis through a genome-wide CRISPR screen, revealing its role in actin depolymerization and lysosomal acidification.

This study identifies XCT as a circadian clock regulator in Arabidopsis that influences RNA splicing and the circadian clock through distinct genetic pathways.

This study identifies genetic factors associated with glyceollin induction in wild soybeans using metabolite-based genome-wide association, finding SNPs and gene clusters linked to this trait.

The paper identifies the abfA cluster as a key genetic factor for arabinan utilization in gut microbiota, showing its therapeutic potential for constipation through improved gut motility and metabolite production.

This study identifies two Lactobacillus strains with probiotic properties for vaginitis treatment using genomic analysis, in vitro tests, and in vivo experiments.

This paper demonstrates a method to edit the brain genome in mammals using focused ultrasound to temporarily open the blood-brain barrier for CRISPR/Cas9 delivery via intravenous injection.

This study uses computational models to show that weak-rectified gap junction coupling and electrically isolated distribution of bio-pacemaker cells enhance their pacing efficiency.

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

This paper identifies and engineers a high-fidelity Cas12i variant with broad PAM recognition and minimal off-target activity for improved genome editing.

This study reports the formation mechanism of twinning β-form anhydrous guanine microplatelets in scallop eyes, revealing an intermediate amorphous phase and a two-step crystallization process.