H. Zhang

This study investigates the cardiac electrophysiological effects of hydroxychloroquine and azithromycin, showing they prolong QT intervals and increase arrhythmia risk when combined.

The paper examines age-related changes in T cell responses by analyzing transcriptional and epigenetic profiles of naive CD4+ T cells from young and older adults, identifying increased epigenetic remodeling and effector cell differentiation.

This study creates a murine model with JAK2V617F in both hematopoietic and vascular cells, showing it mimics human MPN features like disease progression and cardiovascular issues.

This study simulates reentrant arrhythmias in ischemic hearts with multiple electrophysiological remodelling stages, showing that spatial heterogeneity of refractory periods and excitation threshold differences drive reentry depending on border orientation relative to wavefronts.

This study identifies tumor-specific peptides in pediatric brain tumors using proteogenomics to enable personalized T cell immunotherapy.

This paper develops a bispecific antibody, 2022, that neutralizes SARS-CoV-2 and its variants with high potency, showing strong prophylactic and therapeutic effects in a mouse model.

This paper develops a novel PROTAC, ZL216, using an aptamer as a targeting ligand to selectively degrade nucleolin in breast cancer cells, inhibiting their proliferation and migration.

The paper identifies four σ28-dependent sRNAs regulating flagella biosynthesis in E. coli, showing varied effects on flagellin levels, flagella number, and motility.

This study shows that Bacillus velezensis SQR9 uses a type VII secretion system to acquire iron from plant roots, enhancing its colonization.

The paper identifies TAZ as a molecular switch driving phenotypic transition and metastasis in SCLC by analyzing mouse models and human data.

The paper introduces a mass spectrometry platform combining acoustic droplet ejection, open-port interface, and electrospray ionization for high-speed, label-free analysis across multiple applications.

The paper investigates microbiota dynamics and assembly patterns in a large water diversion canal, finding deterministic processes shape bacterial communities while stochasticity dominates micro-eukaryotic communities.

This paper introduces IsoNet, a deep learning tool that reduces resolution anisotropy in cryoET data, improving structural interpretability without sub-tomogram averaging.

This study classifies wheat WAKs and WAKLs, identifies structural features, and shows that TaWAK75 and TaWAK76b are involved in resistance to Bgt.

The paper identifies ProXs, proteins capable of forming membraneless organelles in plants, and shows their conservation across species.

This study quantifies how Vibrio cholerae lands on surfaces in viscoelastic environments using MSHA pili and flagellum, showing pili act as brakes and anchors during landing.

The paper identifies 41 viral clusters in groundwater plasmidomes, links them to bacterial hosts, and detects novel phage genera and host-specific genes.

This study meta-analyzes DNA metabarcoding and traditional methods for aquatic community assessment, finding congruence for fish but complementarity for microorganisms and macroinvertebrates.

This study designs artezomibs, artemisinin-proteasome inhibitor hybrids, which overcome resistance in Plasmodium falciparum by targeting proteasomes, including those with mutations.

This paper designs a trimeric RBD vaccine candidate with mutations from multiple SARS-CoV-2 strains, showing broad neutralization against variants including Beta and Kappa.

This paper develops a droplet-based microfluidics platform for high-throughput functional antibody screening, identifying potent cancer immunotherapeutics like CD40 agonists and anti-Her2/anti-CD3 bispecific antibodies.

This study shows that amitosis in Tetrahymena provides evolutionary benefits similar to sex, enabling long-term success of asexual lineages by reducing mutation load and accelerating adaptation.

This study identifies two types of scales in an Early Cretaceous bird fossil, suggesting all four modern bird scale types existed by that time.

This study investigates H3K27 demethylation during Arabidopsis germination, showing REF6 establishes a transcriptionally permissive state by counteracting PRC2 activity.

The paper identifies CD73-expressing memory T cells that decline with age and are functionally distinct, with potential interventions to improve immune memory in older adults.

This study identifies a novel constitutive MLS resistance in S. haemolyticus and shows that ErmC deletion causes resistance while continuous ErmC expression imposes a growth cost.

This study identifies SARS-CoV-2 ORF8 as a protein that downregulates MHC-I to evade immune detection by promoting lysosomal degradation, reducing CTL-mediated cell elimination.

The paper reports crystal and cryo-EM structures of human CCKAR and CCKBR with ligands, revealing ligand recognition and activation mechanisms.