L. Liu

This study investigates changes in mechanical properties and nanomorphology of BMSCs during early apoptosis using AFM and other techniques, finding that mechanical damage precedes apoptotic signals.

This paper shows overexpression of ELO2 in yeast increases complex sphingolipids, improving osmotic tolerance and cell survival under high salt conditions.

This study compares the shapes and sizes of prostate lesions in dogs treated with laser, radiofrequency, and microwave ablation, finding significant differences in lesion morphology and volume.

This study shows that effector T cells use inosine as an alternative carbon source under glucose restriction, enhancing anti-tumor function and bypassing tumor-imposed metabolic limitations.

This paper introduces a high-throughput platform that links optical and gene expression profiling of single cells, demonstrating accurate measurements from thousands of cells and characterizing DNA and RNA changes in Jurkat cells through the cell cycle.

This paper introduces a multi-dimensional separation method for glycosaminoglycan oligosaccharides that enables structural and functional analysis without desalting.

This paper demonstrates an enzyme-free method to synthesize natural phospholipids in water, forming cell-like membranes and establishing proton gradients.

The paper develops a droplet-digital Cas13a assay for single-molecule microRNA quantification, demonstrating its precision, specificity, and broad applicability.

This study investigates how terminal tagging affects the oligomerization of the sigma 1 receptor using a modified Western blot protocol, revealing that the N-terminus influences ligand binding effects while the C-terminus is more suitable for modifications.

The paper identifies dysbiosis in RA tonsillar microbiota and shows that Streptococcus salivarius and its antibacterial peptides modulate autoimmunity by suppressing T cells and autoantibodies.

This study shows that ERAD preserves HSC quiescence and self-renewal by restricting mTOR activity, preventing HSC depletion and hyper-proliferation.

This study shows that ginsenoside Rg1 protects PC-12 cells from hydrogen peroxide damage by up-regulating miR-216a-5p, which reduces apoptosis and autophagy.

This paper identifies false-positive peptide inhibitors of KRas using orthogonal assays and cellular screens, highlighting the need for rigorous validation in drug discovery.

This paper identifies and characterizes an NAD-dependent xylitol dehydrogenase from Gluconobacter oxydans WSH-003, showing high activity for D-sorbitol to D-fructose conversion and distinct optimal conditions.

The paper determines the absolute protein stoichiometry of carboxysomes and reveals their organizational variability in response to microenvironmental changes.

This study shows that low concentrations of melatonin promote cotton seed germination by enhancing antioxidant enzyme activity, reducing MDA, and modulating plant hormones like ABA and GA3.

The paper identifies intronic heterochromatin as a mechanism suppressing cryptic transcription initiation by TEs in Arabidopsis.

This study shows that G3BP domains are required for alphavirus replication complex clustering and translation initiation, with SFV and CHIKV relying on different G3BP domains for replication.

This study evaluates bio-bitumen made from biomass pyrolysis oil as a substitute for petro-bitumen in coating sheets, showing improved adhesion, temperature stability, mechanical strength, and flexibility.

This paper introduces a heterogeneous loop model to infer 3D chromosome structures from Hi-C data and validates it against experimental measurements.

This study introduces SLHC-seq, a new targeted sequencing method that improves detection of pancreatic cancer by analyzing short mutant cfDNA fragments, enabling earlier diagnosis.

This study investigates the selectivity of 4-aminoquinolines for the alpha2A-adrenoceptor using docking, molecular dynamics, and mutagenesis to identify binding sites and affinity determinants.

This study shows that pre-infection modulation of host glycolysis with 2-DG enhances resistance to M. marinum infection by reducing phagocytosis and bacterial proliferation.

This paper identifies niclosamide and nitazoxanide as potent TMEM16A antagonists that fully bronchodilate airways, offering new treatment options for severe asthma and COPD.

This study shows that TLR3 deficiency worsens epithelial barrier loss in genital tract Chlamydia muridarum infection, as measured by transepithelial resistance and tight-junction gene expression.

This paper introduces ICO-seq, a method to profile gene expression in large numbers of yeast colonies, and applies it to study gene expression heterogeneity in engineered yeast strains.

This study identifies Lsm12 as a regulator that mediates Polη deubiquitination to enhance its recruitment and improve survival under oxidative stress in yeast.

This study assesses the acute and chronic toxicity of benzylpenicillin G residues in heat-treated animal food products using a mouse model, finding reduced LD50 and organ damage at high exposure levels.

The paper analyzes anti-V2 antibody levels in HIV-1 infected individuals and finds that some show deficiency, which correlates with viral V2 region characteristics.