L. Ma

This study identifies a novel gene, srpA, in Streptococcus suis that confers resistance to multiple ribosome-targeting antibiotics by altering ribosome binding.

This study shows that knocking out OsSWEET15 in rice reduces fertility by impairing embryo formation and seed-setting, with similar effects observed in OsSWEET11 mutants.

This paper introduces SpRYgests, a CRISPR-based DNA cloning method that enables precise cleavage at any sequence, improving cloning workflows and reducing costs compared to restriction enzymes.

The paper develops a hybrid MELD-NMR approach to determine structures of flexible protein-polypeptide complexes using only NMR chemical shift data, achieving accurate results for ET domain-BET protein interactions.

This study identifies a new structural class of fungal effectors in Fusarium oxysporum f. sp. lycopersici using experimental and computational methods, revealing structural relationships and immune recognition mechanisms.

The paper identifies GbNGT1, an N-glucosyltransferase that catalyzes IAA and IAA-amino acid glucosylation, completing the auxin metabolic pathway.

The paper compares DNA and RNA microbial communities in Miscanthus x giganteus soil under different nitrogen fertilization rates, finding RNA-based communities better reflect nitrogen-cycling taxa.

The paper introduces Yn situ, a single RNA molecule in situ detection method, showing it is sensitive and quantitative for gene expression in mouse olfactory epithelia.

The paper shows that kidney injury affects cell clustering in scRNA-Seq by reducing specific cell groups and markers, emphasizing the need for histology screening before analysis.

This paper improves the production of disulfide-bonded fungal effectors in E. coli using CyDisCo and FunCyDisCo co-expression systems, enabling functional studies and crystallisation.

The paper introduces a universal microfluidic method for studying bacterial biofilms, demonstrating insights into H2O2 resistance and resource retention mechanisms in E. coli and P. aeruginosa biofilms.

This study shows that the intracellular glycosyl hydrolase PslG affects signaling, ePsl structure, cyclic-di-GMP levels, and biofilm formation in Pseudomonas aeruginosa.

This study shows that maternal exposure to dibutyl phthalate during pregnancy and lactation leads to increased visceral obesity in adult female offspring without affecting serum glucolipid levels or the PI3K/AKT pathway in muscle.

This paper introduces a CRISPR-nCas3 system for efficient genome editing in bacteria, enabling high-efficiency deletion of large genomic regions.

The paper shows YBX1 phase separation enables selective sorting of miR-223 into exosomes by recruiting it into condensates that facilitate RNA packaging.

OsciDrop generates size-tunable, monodisperse droplets on demand without microfabrication, enabling chip-free droplet assays for applications like virus quantification.

The paper identifies enhancer heterogeneity in gastric cancer by integrating epigenomic data and functional assays, linking it to genetic and regulatory factors.

The paper investigates how complexin-1 regulates the assembly of SNARE complexes by stabilizing partially folded states and interacting with specific regions of SNARE proteins.

This study evaluates updated SARS-CoV-2 mRNA vaccines in mice, showing that mRNA-1273.351 boosts neutralization against B.1.351 and mRNA-1273.211 provides broad cross-variant protection.

This study shows sustained oxygenation improves diabetic wound healing by enhancing epithelialization, angiogenesis, and reducing inflammation without drugs.

This study identifies BIRG1 as a chloride efflux transporter in rice that regulates grain size and salt tolerance by controlling chloride homeostasis.

This study shows that apoptotic extracellular vesicles (apoEVs) protect liver homeostasis and regeneration by forming a chimeric organelle with the Golgi apparatus and restoring hepatic ploidy.

The paper shows that complement activation is higher in severe SARS-CoV-2 infection compared to influenza and non-COVID respiratory failure, with the alternative pathway linked to worse outcomes.

This study shows that inhibiting VTA dopamine neurons reduces risky decision-making and impulsivity in male rats but increases risky choices in females, while also reducing cocaine-induced decision-making deficits but increasing cocaine consumption.

This study evaluates mRNA-1273 vaccine efficacy in hamsters, showing reduced pulmonary immune activation and improved disease outcomes after prime-boost vaccination.

This paper generates human stem cell models of CLN2 disease by introducing pathogenic TPP1 mutations using CRISPR/Cas9 and validates their reduced TPP1 enzyme activity.

This study determines the crystal structure of pDLA-88*001:01 and identifies its peptide-binding motif, revealing structural differences between two categories of DLA-88 alleles in dogs and their implications for antiviral immunity.

This study introduces a multi-enzyme directed evolution model to improve screening throughput and efficiency, revealing convergent evolution in two cytochrome P450 enzymes with distinct active sites achieving similar functions.

This study identifies multiple HIV-1 escape mechanisms from PGT135 in a slow progressor, highlighting the role of glycan sites and V1/V4/C2 region changes in antibody resistance.

This study compares the urinary microbiome in postmenopausal women with and without recurrent UTIs, finding no significant differences in Lactobacillus abundance but identifying anaerobic taxa differences associated with UTI recurrence.