S. Wang

This study identifies stemness-related genes in human CD34+ cells from different sources and culture conditions using scRNA-seq, revealing pathways involved in stemness maintenance and potential drug targets for HSC expansion.

The paper derives exact solutions for membrane fusion pores, identifying three families and showing dilation involves transitioning from a narrow to wide pore with an intermediate unstable state.

The paper assesses Trichodesmium diversity in the Red Sea using metagenomes and hetR gene phylotyping, finding that morphology and marker genes may not reliably reflect genetic diversity.

The paper identifies that memory precursor cells are continuously generated over time following acute infection, with increased numbers and effector gene expression observed later.

This paper introduces single-objective evanescent scattering microscopy for label-free single protein imaging and binding kinetics quantification with high spatiotemporal resolution.

This study shows that aucubin promotes functional recovery after spinal cord injury by reducing inflammation and neuronal apoptosis through the TLR4/NF-κB pathway and mitochondrial protection.

This study identifies a novel gene, srpA, in Streptococcus suis that confers resistance to multiple ribosome-targeting antibiotics by altering ribosome binding.

This study compares slow-cycling cells with cancer stem cell (CSC)-like cells in glioblastoma, showing phenotypic and functional heterogeneity and supporting the cancer stem cell mosaicism model.

This study uses metagenomics to characterize microbial community structure and metabolic capacity in Bamucuo, Tibet, identifying new species and metabolic pathways.

This study evaluates ACE2-Fc combined with neutralizing antibodies against SARS-CoV-2 variants, showing enhanced neutralization and resistance to escape mutations.

This study reports cryo-EM structures of S1PR1 bound to different agonists, revealing activation mechanisms and a two-step transition process for CBP-307.

The paper uses spatial single-cell analysis to show that CD73 and CD39 expression in glioblastoma correlates with poor clinical outcomes and immunosuppressive signaling.

This study examines the structural, functional, and antigenic properties of the SARS-CoV-2 Omicron spike protein, revealing its enhanced immune evasion and altered fusogenic capability due to mutations.

This study identifies PBP2 as the primary target of cephalosporins in C. difficile and reveals a unique Zn2+-binding motif in PBP2 and related PBPs that contributes to cephalosporin resistance and sporulation.

The paper designs and produces molecular probes for SARS-CoV-2 variants to assess immune responses and isolate neutralizing antibodies.

This study shows that ALA-PDT kills drug-resistant M. marinum in vitro and in a mouse model, leading to recovery of cutaneous lesions and clinical improvement in two patients.

The paper shows host APOBEC3A, APOBEC1, and APOBEC3G edit SARS-CoV-2 RNA, promoting viral replication and suggesting APOBEC-mediated mutations contribute to viral evolution and new strain emergence.

This study uses single-cell RNA-sequencing to analyze immune cell diversity across 12 species, revealing conserved and divergent molecular mechanisms and cellular interactions.

The paper digitally reconstructs pectoral girdles of two Early Cretaceous birds, revealing morphological features and their implications for early flight evolution.

This study uses artificial selection on H. axyridis to investigate how invasion syndromes evolve, finding that selecting on age at first reproduction leads to more widespread phenotypic changes than selecting on body mass.

This study isolates and characterizes Cryptococcus neoformans capsule polysaccharides using physical and enzymatic methods, revealing that the capsule is assembled from smaller polymers added distally.

The paper presents a longitudinal multi-omics dataset of human fibroblasts with mitochondrial perturbations to study aging mechanisms and bioenergetics.

The paper shows that age-induced P-bodies in yeast shorten lifespan and are detrimental, with cytosol acidification exacerbating this effect.

The paper identifies IgA-secreting AT2-like cells in fibrotic lungs and shows their role in ECM IgA deposition through spatial transcriptomics and scRNA-seq.

The paper identifies GbNGT1, an N-glucosyltransferase that catalyzes IAA and IAA-amino acid glucosylation, completing the auxin metabolic pathway.

This study identifies natural killer-like B cells as pathogenic in rheumatoid arthritis by promoting Th17 differentiation and disease severity.

This study identifies ecDNA in 18% of medulloblastoma patients, linking it to higher relapse and mortality rates and suggesting enhancer rewiring as an oncogenic mechanism.

The paper identifies SeASF1 and SeH4 as regulators of the PI3K/AKT pathway in filamentous ascomycete, influencing sexual and asexual development through interactions with SeDJ-1 and SePI3K.

This study identifies FOXP4 as a regulator of beige adipocyte differentiation and thermogenesis, showing it suppresses thermogenic potential in preadipocytes but enhances it in mature adipocytes.

This study uses single-cell RNA sequencing to show heat shock proteins promote BCC growth in response to WNT5A-mediated inflammatory signals from the tumor microenvironment.