X. Song

This study shows R13, a TrkB agonist, improves mitochondrial function and reduces AD-related pathology in 5xFAD mice by enhancing biogenesis and metabolism.

This study identifies altered gene expression and cell interactions in oocytes and cumulus cells of PCOS patients, highlighting dysregulated microtubule genes and transposable elements.

This study investigates a fermented Yi traditional medicine, JB10, showing significant in vitro suppression of SARS-CoV-2 replication with EC50 of 769.1 dilutions and a selection index of 42.68.

The paper identifies a feedback loop between Astrin-PP1 and CyclinB-CDK1 that stabilizes mono-oriented chromosome-microtubule attachments independent of biorientation.

This study finds a significant association between Kaposi's Sarcoma Herpesvirus (KSHV) infection and osteosarcoma in the Xinjiang Uyghur population, identifying KSHV as a potential risk factor and a newly identified viral-associated cancer.

The study analyzes the urinary microbiota of 147 Chinese women, revealing non-sterile urine with distinct bacterial communities and showing similarity to cervical and uterine microbiota rather than vaginal microbiota.

This study examines how furfural residue amendments affect rhizosphere microbiota diversity and composition in long-term maize monocropping, showing increased beneficial microbes and reduced pathogens.

A mouse-adapted SARS-CoV-2 strain with RBD mutations caused 100% mortality in aged male BALB/c mice and showed altered receptor binding affinity.

This study establishes a mouse model of renal cell carcinoma showing that 9p21 loss drives aggressive tumor evolution with chromosomal instability and metastasis.

The paper identifies leukemia stemness and co-occurring mutations as drivers of resistance to IDH inhibitors in AML through genomic analyses of treated patients.

This study uses single-cell DNA sequencing to analyze clonal diversity in AML, revealing mutation co-occurrence, mutual exclusivity, and evolutionary patterns linked to treatment resistance and poor prognosis.

The paper investigates how temporal changes in functional traits and neighborhood crowding affect tree growth in a tropical forest, finding that dynamic factors better predict growth rates than static ones.

This study develops a model to characterize cell membrane mechanics using relaxation curves from optical tweezers, revealing insights into cell skeleton changes and protein diffusion.

This paper describes a phage that targets human glycans to enhance its activity in the gastrointestinal tract by positioning it near bacterial hosts.

The paper examines ACE2 expression on immune cells and finds that activated type 1 macrophages (M1) have high ACE2 expression, suggesting they may be targeted by SARS-CoV-2.

The paper develops a biparatopic antibody-ACE2 fusion (89C8-ACE2) that effectively blocks SARS-CoV-2 infection in vitro and neutralizes authentic virus at low nanomolar concentrations.

This study identifies potential mechanisms of celastrol's anti-inflammatory effects in rheumatoid arthritis by analyzing transcriptomic and proteomic changes in fibroblast-like synoviocytes.

This paper identifies a potent neutralizing antibody targeting the N-terminal domain of SARS-CoV-2 Spike protein, revealing it as a new therapeutic target.

The paper determines the crystal structure of the MBTD1-EPC1 complex, revealing the molecular mechanism of MBTD1 recruitment into the NuA4/TIP60 acetyltransferase complex.

This study shows rottlerin reduces DSS-induced colitis in mice by enhancing intestinal barrier function through the Epac-2/Rap-1 signaling pathway.

This paper presents a dataset of speed-resolved blood perfusion and oxygen saturation in human skin under thermal stimulation and control conditions.

This study shows that deletion of RgsA in Pseudomonas aeruginosa reduces growth and oxidative stress resistance in both planktonic and biofilm states.

This study evaluates a novel three-dimensional grid intrauterine device (3-DGIUD) in rhesus macaques, finding it effective for contraception without significant impact on endometrial steroid receptors and PAX2 expression.

The study investigates the impact of Bt-506 corn leaf litter on Collembola and decomposition rates, finding no significant effect of Bt protein but differences due to litter composition.

This study shows that effector T cells use inosine as an alternative carbon source under glucose restriction, enhancing anti-tumor function and bypassing tumor-imposed metabolic limitations.

This study shows that germline RNA helicases regulate P granule formation and disassembly through RNA binding and release, with FGG repeats promoting perinuclear localization, and links defects in this process to fertility issues in C. elegans.

The paper describes a microfluidic device to study metabolic landscapes in yeast colonies, showing glucose gradients and their impact on growth and gene expression.

This study develops a fluorescent probe to measure glutathione concentrations in the nucleus and cytosol, finding no significant concentration gradient between them.

This study isolates and characterizes Bacillus amyloliquefaciens subsp. plantarum XH-9, showing it promotes plant growth and suppresses Fusarium oxysporum in wheat.