X. Yu

This study investigates the conserved allosteric inhibition mechanism of SLC1 transporters EAAT1 and ASCT2 using cryo-EM, kinetic experiments, and computational modeling, showing that UCPH-101 inhibits EAAT1 and partially inhibits ASCT2 with lower affinity.

This study identifies IL-22 as a key immune-to-brain signal that reduces stress-induced anxiety by acting on septal neurons.

This study shows lactate enhances CD8+ T cell stemness and improves anti-tumor immunity by increasing Tcf7 expression through histone acetylation.

This study identifies a cryptic transactivation domain of EZH2 that binds AR and AR-V7, promoting oncogene activation and tumorous transformation, and shows that targeting this interaction with a PROTAC reduces tumor growth.

This study identifies a conserved Trp-Pro motif in PPARγ AF-1 that undergoes cis/trans isomerization, enabling interdomain communication with the LBD and affecting transcriptional activity.

The paper curates a combined transcriptome dataset of prostate cancer cell lines and provides a visualization platform for gene expression analysis.

This study determines the structures of perforin-2 in solution and on membranes, revealing its conformational transition mechanism during pore formation.

This study shows Aspergillus tabacinus LZ-M can degrade acid red 73 anaerobically through a self-redox mechanism, mineralizing it to CO2 with a 90.28% decolorization rate in 5 days.

The paper shows that β-galactoglucomannan (β-GGM) in eudicot primary cell walls is structurally and functionally similar to xyloglucan (XyG).

This study shows that suppressing CMTM6 in tumors or hosts enhances anti-tumor immunity independently of PD-L1, suggesting CMTM6 as a target for gene therapy.

This study identifies bZIP25 and bZIP53 as transcription factors regulating pavement and trichome cell development in Arabidopsis thaliana using single-cell RNA-sequencing.

This study identifies WDR5 as an epigenetic regulator that promotes breast cancer growth and metastasis through KMT2-independent translation regulation, suggesting therapeutic strategies targeting WDR5.

This study uses cryo-electron tomography to reveal the 3D organization of Rubisco in two types of carboxysomes from different bacteria, showing distinct structural arrangements and responses to calcium treatment.

The paper identifies a broadly neutralizing epitope in SARS-related coronaviruses that is effective against variants, including Omicron, and suggests its use for universal vaccine design.

This paper introduces Spinning Disk Multifocal Microscopy (SDiM) for high-speed, high-resolution imaging of large biological surfaces, demonstrating its application in cortical and immune cell studies.

This study profiles the site-specific glycosylation patterns of ebolavirus GP using mass spectrometry, revealing complex N-, O-, and C-linked glycans that contribute to the glycan shield and restrict antibody neutralization.

The paper identifies the X chromosome of the Asian citrus psyllid and compares transcription and DNA methylation between male and female adults, finding sex-specific patterns and no direct link between methylation and gene expression.

This paper develops bright fluorophores and uses heavy water to improve fluorescence imaging of deep-buried hollow organs, achieving better visualization and diagnosis.

This paper introduces a method to discover rare rabbit monoclonal antibodies against small molecules using an indirect competitive screening approach, resulting in a highly stable antibody with exceptional halophilic properties.

This study compares the membrane-binding properties of Plasmodium vivax PLP1 and PLP2 with Toxoplasma gondii PLP1 using structural and functional analyses.

This study identifies how oncogenic RAS activates mTORC1 in multiple myeloma by co-opting amino acid sensing pathways through a novel signaling complex.

The paper shows that chromosome 1q amplification promotes melanoma metastasis by overexpressing ceRNAs that sequester tumor suppressor miRNAs.

This study identifies and characterizes quiescent stem cells in the mammalian esophageal epithelium using scRNA-seq and DNA methylation profiling in rat models.

This study shows that e-cigarette aerosol increases cardiovascular oxidative stress in mice with the ALDH2*2 genetic variant, leading to higher ROS, protein damage, and NF-kB activation.

The paper reveals TACAN is a homodimer with lipid-associated domains and suggests membrane lipids coordinate with the protein to sense mechanical signals.

This paper identifies macrocyclic peptides that inhibit KRAS signaling by binding to its hydrophobic pocket, showing on-target activity and improved proteolytic stability.

The paper examines S. commune fruiting bodies and hyphae to confirm the presence of calcium oxalate crystallites, demonstrating biomineralization in this fungus.

This study identifies a lineage of antibodies from infected rhesus macaques that neutralize 54% of HIV-1 strains by expanding the antibody-Env interface around the V2 loop.

This study identifies small molecule inhibitors of SARS-CoV-2 entry through high-throughput screening and validates Calpeptin as a potent inhibitor of SARS-CoV-2 and some variants.

This study compares the in vitro efficacy of four oxazolidinones against rapid-growing Mycobacteria isolates from Beijing, finding tedizolid most effective against M. abscessus and delpazolid against M. fortuitum.