Z. Hu

This study shows that alveolar regeneration after viral infection occurs independently of tuft cells, with ectopic basal progenitor cells generating alveolar epithelial cells through distinct differentiation paths.

The paper shows TBK1 phosphorylates TNIP1, activating its LIR-dependent autophagy-mediated degradation, which promotes pro-inflammatory gene expression.

This study shows that eosinophils migrate to the lungs early after Mycobacterium tuberculosis infection in mice and macaques, mediated by GPR183 and Ch25h, independent of CCR3.

This study investigates how benzothiadiazine derivatives interact with cell membranes using molecular dynamics simulations, finding strong interface affinity and varied solvation characteristics.

This study shows that knocking out OsSWEET15 in rice reduces fertility by impairing embryo formation and seed-setting, with similar effects observed in OsSWEET11 mutants.

The paper investigates the role of the intrinsically disordered region (IDR) in coronins, showing it fine-tunes oligomerization and actin polymerization through evolutionary conserved patterns.

This study identifies integrin-mediated adhesion and FAK/PYK2 signaling as critical for myeloid cell support of T-ALL, showing their role in survival and progression.

The paper identifies a short prokaryotic argonaute (pAgo) in Sulfolobus islandicus that, along with Aga1 and Aga2, provides antiviral defense through abortive infection.

The paper introduces a framework and software for optimizing and reproducibly analyzing multiplex imaging data, focusing on cyclic immunofluorescence.

This study identifies METTL3's role in promoting homologous recombination repair and modulating chemotherapeutic response in breast cancer cells by regulating the EGF/RAD51 axis through m6A modification.

This study shows that humanized mice can be infected by SARS-CoV-2, leading to immune responses and immunopathology, providing a model for studying the virus and testing therapies.

This study identifies JM03, a crotamiton derivative, as a small molecule that extends C. elegans lifespan and improves stress resistance by inhibiting OSM-9 and activating SKN-1 signaling.

This study identifies SPRR1 and SPRR2 as antimicrobial proteins produced by sebocytes that defend the skin by disrupting bacterial membranes, showing increased susceptibility to infections in their absence.

This study investigates benzothiadiazine interactions with zwitterionic phospholipid membranes using molecular dynamics simulations to understand its behavior and binding mechanisms.

This study shows eosinophils are recruited to tuberculosis-infected lung tissue in mice and contribute to host resistance against Mtb infection.

This study develops an IFN-armed RBD dimer vaccine that induces strong neutralizing antibodies and T cell responses, offering complete protection against SARS-CoV-2 in rhesus macaques with a single dose.

This study tracks the genomic evolution of ST11-CRKP during antibiotic therapy in a patient, identifying mutations linked to reduced virulence and increased host adaptation.

The paper examines ethical issues in disease naming and proposes a method using deep learning to find suitable substitutes for outdated disease names.

The paper shows membrane surfaces control the size and position of ribonucleoprotein condensates by altering diffusion rates of proteins and nucleic acids.

The paper studies a rare bamboo rhizome phenomenon with excessive shoots, analyzing its associated microbiome and finding correlations between bacterial genera and shoot numbers.

The paper investigates the metapopulation structure of marine bacteria associated with diatoms, finding that closely related bacterial populations are host-specific and show functional differentiation.

This study identifies tankyrase-mediated ADP-ribosylation as a regulator of TNF-induced cell death by promoting complex 2 assembly and interacting with RNF146.

This study evaluates the neutralization of SARS-CoV-2 501Y.V2 variant by antisera from two Chinese vaccines, showing preserved neutralizing titres against the variant.

This paper presents an OMS Atlas from serial biopsies of a metastatic breast cancer patient, linking clinical data to multi-omic and spatial profiles to study therapy-associated heterogeneity and resistance mechanisms.

This study develops and tests a recombinant RBD-Fc vaccine against SARS-CoV-2, showing protection in non-human primates and mice.

The paper develops a genomic resource of 1,500 soybean genomes with 32 million SNPs to enable post-genomic research and applications like QTL discovery and trait allele identification.

The paper identifies ARID1A deficiency's role in promoting pancreatic tumorigenesis by reducing KRAS-induced senescence through upregulation of ALDH1A1 in mouse PanIN models.

This study investigates the association between IFNL4 genetic variants and HCV-related cirrhosis and HCC risk, finding protective effects against cirrhosis and increased HCC risk in specific populations.

This study develops TRAFTACs, chimeric oligonucleotides that degrade transcription factors via proteasomal pathway, and demonstrates their effectiveness on NF-κB and brachyury.

The paper characterizes a clinical Enterobacter hormaechei strain co-carrying blaNDM-1, blaIMP-4, and mcr-9.1, highlighting the convergence of resistance genes in an epidemic clone.