Z. Sun

The paper presents a cryo-EM structure of ZnT8 at low pH, suggesting protons disrupt Zn2+ coordination, aiding its release into the lumen.

The paper reports the first crystal structure of a coronavirus M protein from batCOV5 and identifies its interaction with the N protein.

This study identifies elevated plasma IL-13 and periostin as type 2 inflammatory biomarkers in prurigo nodularis using clustering analysis of cytokine profiling.

This study shows that Zmiz1 is essential for β-cell function and mass expansion in response to high fat feeding, linking its loss to diabetes.

This study develops a stable and safe mRNA vaccine (cmRNA-1130) using degradable lipid nanoparticles against the SARS-CoV-2 Delta variant, showing potent immune responses and stability.

This study shows that dietary glutamine supplementation enhances antitumor immunity by altering the tumor microenvironment in mice with malignant salivary gland tumors.

The paper identifies a novel human antibody VH domain with high affinity for mesothelin and demonstrates its efficacy in both CAR-T cell and antibody drug conjugate formats against mesothelin-expressing cancer cells.

This study identifies a biparatopic VH domain that neutralizes SARS-CoV-2 VOCs, including Omicron, with high potency in vitro and in a mouse model.

This paper identifies ZAKa-driven ribotoxic stress as a mechanism for activating human NLRP1, leading to pyroptosis in response to UVB and microbial ribotoxins.

This study evaluates the functional effects of 21 common sweeteners on human gut microbiomes using metaproteomics, identifying potential prebiotic properties in certain sugar alcohols.

This study identifies a broadly neutralizing antibody fragment and analyzes spike protein mutations in SARS-CoV-2 variants to understand their structural and functional impacts on antibody evasion.

This study investigates how DNA methylation in transposable elements disrupts the link between 3D chromatin organization and gene expression in rice after genome duplication.

This study identifies and validates multiple novel targets of HSV-1 ICP0 in neuronal cells using proteomic approaches and functional experiments, revealing potential restrictive activities of SNX9 and OTUD4.

This study cultivates Akkermansia muciniphila in a dynamic bionic intestinal reactor with different media, finding higher biomass and specific metabolites under human mucin conditions.

This paper develops a novel circular mRNA (C-RNA) platform for cancer therapy, showing it enhances anti-tumor immune responses and improves protein expression through optimized formulation.

The paper identifies auranofin as a drug that lowers leptin levels in white adipose tissue and improves insulin sensitivity in obese mice, with anti-diabetic effects.

The paper constructs a global microbiome transition network showing microbiomes are closely connected despite habitat differences, with a scale-free structure and a roadmap of dispersal.

This study shows that disrupting rRNA biogenesis in mouse embryonic stem cells induces a 2C-like state through reorganization of peri-nucleolar heterochromatin and activation of the 2C program.

The paper introduces a database that compiles antibody responses and clinical data from COVID-19 patients for analysis and visualization.

This study identifies LENG8 as an mRNA processing factor that regulates mitochondrial activity by controlling mRNA nuclear export and mitochondrial protein expression.

This study shows that complete depletion of linker histone H1 in Arabidopsis disrupts correlations between chromatin compartmentalization, DNA methylation, and gene expression.

This paper develops RNA-based fluorescent sensors to directly image and measure (p)ppGpp in live bacterial cells, revealing cell-to-cell variation and dynamics under different nutritional conditions.

The paper develops the Arabidopsis PeptideAtlas, a proteomics resource integrating mass spectrometry data with metadata and community tools to enhance understanding of the Arabidopsis proteome.

This paper develops a deep learning model to quantify pathological features in kidney transplant biopsies, showing improved prediction of graft loss compared to clinical and Banff scores.

This study shows that the QpH1 plasmid in Coxiella burnetii is essential for colonizing murine macrophages and highlights its role in the bacterium's persistence in rodents.

This study investigates how DNA mispairing affects RecG helicase translocation using AFM, finding that certain mismatches block movement while others do not.

The paper evaluates an antibody domain's ability to neutralize SARS-CoV-2 variants with mutations in the RBD, showing it neutralizes the triple mutation variant but not others.

This study shows that a low sugar diet increases body size in both male and female Drosophila larvae, but affects their insulin/TOR signaling and metabolism differently.

This study shows sulfur limitation increases duckweed starch yield without reducing growth, making it a promising method for biofuel production.

This study identifies MAP2 phosphorylation changes in schizophrenia, linking them to neuronal structure and synaptic function impairments through phosphoproteomics and transgenic mouse models.