F. Li

This study identifies ribosomal protein L23 as a driver of hepatocellular carcinoma metastasis by upregulating MMP9 expression and promoting tumor growth and metastasis in vivo.

This paper develops a CRISPR/Cas13a system combined with super resolution imaging for direct, amplification-free viral RNA detection with improved sensitivity.

This study develops isoform-specific antibodies against VGLUT2 to investigate allosteric inhibition mechanisms and their physiological roles.

The study identifies a secondary metabolite produced by L. reuteri that mediates intraspecies antagonism, with resistance linked to cell wall acetylation.

The paper introduces a method to degrade specific proteins and organelles using engineered autophagy receptors, demonstrating its effectiveness in plant and transient expression systems.

This study demonstrates the in vitro generation of alveolar macrophage-like cells from fetal liver monocytes using GM-CSF, which can engraft in vivo and protect against respiratory infections.

This study reveals the structural basis of SETD2 methyltransferase interaction with hnRNP L paralogs, showing how a leucine pair in SETD2 interacts with hnRNP L RRM2 and affects splicing regulation.

The paper uses cryo-EM and AlphaFold2 to determine the structure of SARS-CoV-2 Nsp2, revealing its zinc-binding site and potential interactions with host proteins.

This study shows that platelet HMGB1 in PRP enhances tendon healing in mice, with PRP from GFP mice promoting faster healing and better tissue organization compared to PRP from HMGB1 KO mice.

This study determines the cryo-EM structure of HCMV Pentamer bound to neuropilin 2 and neutralizing antibodies, revealing molecular interactions and epitopes involved in viral tropism and neutralization.

This study identifies a feline commensal bacterium, S. felis, that inhibits drug-resistant S. pseudintermedius through antimicrobial peptides, showing potential for bacteriotherapy against skin infections.

The paper develops a chemical probe, UNC6934, that targets the PWWP1 domain of NSD2, revealing cooperative control of NSD2 localization through chromatin reader domains.

This study identifies additional ORFs in geminiviral genomes that encode small proteins with specific subcellular localizations and virulence functions.

This study examines how the wild tomato Solanum habrochaites affects the survival, fecundity, and gene expression of the whitefly Bemisia tabaci, revealing stress gene induction and potential for pest control.

This paper identifies SAM competitive inhibitors of SARS-CoV-2 nsp14 methyltransferase and characterizes their mechanism, guiding the development of selective bi-substrate inhibitors.

This study evaluates enzalutamide's antiviral efficacy against SARS-CoV-2 in different cell types and mouse models, finding it effective in prostate cancer cells but not in lung cells or organoids.

The paper develops a radioactivity-based high-throughput screening assay for the SARS-CoV-2 nsp10-nsp16 complex and optimizes it for HTS with a Z'-factor of 0.83.

This study produces SARS-CoV-2 virus-like particles in insect cells for vaccine development and research.

The paper identifies candidate susceptibility genes to wheat stem rust disease by analyzing gene expression changes in susceptible and resistant wheat genotypes and a non-host plant.

This study investigates the role of the abaI/abaR quorum sensing system in Acinetobacter baumannii virulence, showing its impact on growth, biofilm formation, antimicrobial susceptibility, and gene expression.

This study analyzes the spatio-temporal changes in Nanjing's urban thermal environment from 2014 to 2018 and identifies key driving factors behind these changes.

This study identifies FDA-approved drugs that inhibit urease activity in H. pylori, offering potential new treatments for infections.

This study analyzes H7N9 virus genome mutations in human clinical samples to identify potential adaptations during infection.

This study introduces a multi-enzyme directed evolution model to improve screening throughput and efficiency, revealing convergent evolution in two cytochrome P450 enzymes with distinct active sites achieving similar functions.

This study identifies DREB2B as a negative regulator of seed vigor through the ABA pathway in Arabidopsis and cotton, interacting with RCD1 and synergizing with ABI3.

This paper reports the discovery of a first-in-class, highly selective allosteric inhibitor of PRMT6, SGC6870, with potent activity and selectivity in vitro and in cells.

This study shows that calorie restriction affects gut microbiome, which in turn influences metabolism, hormones, and brain function in obese individuals.

The study analyzes the urinary microbiota of 147 Chinese women, revealing non-sterile urine with distinct bacterial communities and showing similarity to cervical and uterine microbiota rather than vaginal microbiota.

This paper develops a droplet-based microfluidics platform for high-throughput functional antibody screening, identifying potent cancer immunotherapeutics like CD40 agonists and anti-Her2/anti-CD3 bispecific antibodies.

This study identifies small-molecule antagonists of the NSD2 PWWP domain that block its interaction with H3K36me2, providing a tool for further investigation of NSD2's role in disease.