X. Xu

This study investigates whether prokaryotic Thoeris TIRs can cross-activate plant TIR-immunity and finds they generate overlapping cADPR isomers but have distinct signaling requirements.

This study identifies Apolipoprotein E's role in Dectin-1-dependent development of monocyte-derived alveolar macrophages during pulmonary β-glucan-induced inflammation.

This study uses ancient DNA to trace tiger evolution, revealing China as a genetic melting pot and resolving taxonomic disputes among tiger subspecies.

This paper develops a droplet-based method for single-cell transcriptome profiling of TCR-T cells, improving recovery and reducing contamination.

This study identifies PLK1 O-GlcNAcylation as critical for cell division and shows its role in suppressing uterine carcinoma through biochemical and mouse model experiments.

This study shows that the Hippo tumor suppressor pathway is activated in growth-arrested melanocytes, preventing melanoma development, and its inactivation allows BRAF-driven melanoma formation.

This paper predicts SARS-CoV-2 antigenic evolution using MLAEP, a deep learning model that identifies mutations associated with immune escape and validates them through experiments.

This study shows EWS-FLI1 promotes premature ageing of biomolecular condensates by catalyzing fibril formation through interactions with EWSLCD.

This study analyzes the nasal microbiome of healthy young adults, revealing sex-specific differences in composition and ecological stability between males and females.

The paper catalogs 19,251 non-human reference genomes from Qinghai-Tibetan Plateau animals, revealing new insights into mammalian gut microbiome diversity and host-microbe interactions.

This study constructs a spatiotemporal MRI atlas of fetal brain development in Chinese fetuses, revealing a central-to-peripheral cortical growth gradient and dynamic structural asymmetry.

This study evaluates the effectiveness of three-dose SARS-CoV-2 vaccination against Omicron BA.2 breakthrough infections and finds that third-dose vaccination significantly reduces infection rates and severity.

This study identifies Slamf9+Spp1+ macrophages in hamsters that promote SARS-CoV-2 clearance and inflammation resolution through spatial transcriptomics and scRNA-seq.

This study identifies FoxP3-mediated inhibition of RyR2 as a mechanism by which regulatory T cells suppress immune responses through reduced calcium signaling and impaired T cell-DC interactions.

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

This study identifies climate-associated genetic variants in Populus koreana and predicts its future climate change vulnerability using genomic and environmental data.

The paper identifies small silencing RNAs targeting PxyMasc, a male-determining gene in diamondback moth, expressed from W-linked retrocopies on the female-specific chromosome.

The paper improves a DNA polymerase's efficiency for unnatural nucleotide incorporation by identifying two key mutations through machine learning and mechanistic analysis.

This study identifies stemness-related genes in human CD34+ cells from different sources and culture conditions using scRNA-seq, revealing pathways involved in stemness maintenance and potential drug targets for HSC expansion.

This study examines the preclinical pharmacokinetics and in vitro ADME properties of GS-441524, showing its stability across species and varying bioavailability, supporting its development as an oral drug candidate for COVID-19.

The paper identifies BC5, an allosteric agonist that modulates BK channel activation by disrupting the coupling between Ca2+ binding and pore opening.

This study optimizes urinary extracellular vesicle isolation methods and detects radiation-induced metabolomic changes using mass spectrometry.

This study uses CT scans to analyze the dental systems of three Jurassic ceratopsians, revealing tooth replacement patterns and dietary strategies that inform their evolution.

This study identifies HMGN5 as a novel epigenetic target in breast cancer by showing it promotes tumorigenesis through STAT3-mediated chromatin regulation and suggests siRNA-based therapy.

This study uses snRNA-seq and Stereo-seq to analyze the immunological microenvironment of cervical squamous cell carcinoma, identifying immune cell clusters and their associations with tumor progression and patient survival.

The paper uses CETSA MS to identify novel crosstalk between brassinosteroid and auxin signaling in Arabidopsis by analyzing the thermal and phospho-proteomes of the GSK3 inhibitor bikinin.

The paper digitally reconstructs pectoral girdles of two Early Cretaceous birds, revealing morphological features and their implications for early flight evolution.

This study evaluates how in vitro digestion of meat and soy proteins differs under gastrointestinal conditions mimicking elderly achlorhydria compared to adults, showing reduced hydrolysis and distinct protein degradation patterns in elderly conditions.

This paper describes a new early-branching armoured dinosaur from the Lower Jurassic of China, providing insights into the early diversification of thyreophorans.

The paper shows that chromosome 1q amplification promotes melanoma metastasis by overexpressing ceRNAs that sequester tumor suppressor miRNAs.