W. Zhang

This paper enhances antibody therapy for breast cancer bone metastasis by engineering antibodies with bone-homing peptides, improving their bone tumor targeting and therapeutic efficacy.

This study shows that inhibiting the IDO1 pathway reduces tumor-infiltrating B cells in melanoma models, suggesting potential therapeutic strategies for solid tumors.

The paper evaluates 887 PCRP antibodies against human transcription factors using ChIP-exo and other assays, identifying 5% as strong candidates and 34% as warranting further testing.

This study shows BRCA mutations in pancreatic cancer alter CAF subtypes, specifically increasing CLU+ CAFs, and links this to HSF1 signaling.

The paper identifies an amphipathic α-helix in Apq12 that regulates NPC biogenesis by modulating Brl1 and Brr6 interactions and phosphatidic acid accumulation at the nuclear envelope.

The paper identifies two circRNAs whose m6A methylation synergistically promotes pulmonary fibrosis by targeting eIF4A3, mediated by METTL3.

The paper develops a dynamic binning method for improved peak detection in lipidomics LC-MS data and compares pre-processing tools for differential compound detection.

The paper determines the cryo-EM structure of the chloroplast ClpP complex and shows how the co-chaperonin inhibits its proteolytic activity.

The paper uses single-cell transcriptomics to profile viral receptor expression in masked palm civets, identifying potential tissue tropisms for 132 viruses.

This paper develops Ub variant inhibitors for JAMM-family DUBs STAMBP and STAMBPL1, showing high affinity and selectivity, with structural insights and improved potency over existing inhibitors.

This study shows that total body irradiation in mice leads to ovarian cysts and granulosa cell tumors, with effects dependent on age and radiation dose.

This study identifies 140 autoantigens from Jurkat T-cells, showing 75% are autoantibody targets and 89% are altered in SARS-CoV-2 infection, linking them to autoimmune and cancer-related pathways.

This study quantifies how Vibrio cholerae lands on surfaces in viscoelastic environments using MSHA pili and flagellum, showing pili act as brakes and anchors during landing.

AFEchidna is an R package that simplifies genetic analysis in breeding datasets by implementing mixed linear models for variance components and BLUP predictions.

This paper introduces a 3D single-molecule super-resolution microscopy method to study protein distribution at the nano-bio interface with 10-20 nm precision.

This paper shows that nanoscale surface topography reduces focal adhesions and cell stiffness by enhancing integrin endocytosis, mimicking the effects of soft substrates on rigid materials.

This study demonstrates a T4 phage-based vaccine platform that incorporates M2e antigens, showing high immunogenicity and complete protection against influenza without adjuvants.

The paper identifies IL20RA as a key factor preventing ovarian cancer metastasis through immune crosstalk with peritoneal mesothelial cells.

This study investigates SARS-CoV-2 infection in placentas from infected pregnant women, finding that the virus infects syncytiotrophoblast cells and triggers maternal immune cell infiltration.

The paper analyzes multi-omics data from fibroblasts at the tumor edge and core to show O-glycosylation of the CDK4-pRB axis is induced by tumor-stroma crosstalk.

This paper identifies aCPSF1 and terminator U-tract synergy in archaeal transcription termination, showing their roles in determining termination efficiency through KH domain binding and nuclease activity.

This study investigates how two first-generation MsbA inhibitors, TBT1 and G247, induce opposite allosteric effects by binding to distinct sites in the transmembrane domains.

The paper identifies a novel lineage of SARS-related coronaviruses from bats that use bat ACE2 receptor but not human ACE2, suggesting potential zoonotic risks.

The paper shows that CRISPR-Cas13 can reduce RNA in plants without the Cas13 protein, using a mechanism similar to RNAi.

The paper maps nuclear pore complex assembly in human cells, revealing two distinct molecular mechanisms with different orders of component addition.

This study identifies the enzymes responsible for biosynthesizing the N-hydroxytriazene pharmacophore in triacsins, revealing two ATP-dependent enzymes involved in consecutive N-N bond formation.

This study shows a single intranasal vaccination with inactivated Acinetobacter baumannii rapidly protects mice against pneumonia by training alveolar macrophages, with effects observed against other Gram-negative bacteria but not Gram-positive ones.

This study introduces a new microscopy technique combining deep learning and light-sheet design to visualize organelle interactions in live cells with high spatial and temporal resolution.

This study identifies vitronectin-integrin signaling as a mechanism by which pericytes regulate blood-CNS barrier integrity through inhibition of transcytosis in endothelial cells.

This paper develops a deep learning model to quantify pathological features in kidney transplant biopsies, showing improved prediction of graft loss compared to clinical and Banff scores.