Y. Peng

The paper uses molecular dynamics simulations to show that DNA methylation at CpG sites alters nucleosome geometry, stability, and unwrapping behavior.

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

This study identifies ARID1A deficiency as a biomarker for PLK1 inhibitor sensitivity by revealing a mitochondrial metabolic vulnerability in these cells.

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

This study maps genetic diversity across Zea species, identifying millions of variants and adaptive genes, and demonstrates their utility in breeding.

This study meta-analyzes 193 studies to compare single visit pollination effectiveness across plant visitors, finding honeybees are less effective than many non-honeybee pollinators.

This study shows that two rice pests, the brown planthopper and the rice striped stem borer, cooperate by jointly attacking rice plants, improving plant quality and reducing parasitism risk.

This study shows TPD52 inhibits AMPK activity, leading to metabolic defects in mice, highlighting its role in cancer metabolism.

This study shows that gut microbiota in Anopheles stephensi affects tryptophan metabolism, with Pseudomonas alcaligenes reducing 3-HK to protect against Plasmodium infection.

This study identifies JAM2 as a prognostic marker and potential predictor of immunotherapy response in breast cancer using multi-database analysis.

The paper uses molecular dynamics simulations to study how histone tails modulate nucleosome DNA accessibility and protein binding, revealing distinct binding modes and competitive interactions.

This paper develops a whole-genome MLST (wgMLST) scheme for Bordetella pertussis to improve molecular typing and genomic surveillance, revealing greater resolution in population structure and outbreak analysis.

The paper identifies Lgt inhibitors that remain effective against E. coli even when lpp is deleted, showing Lgt is a robust antibacterial target.

This study identifies a Krt5-BMP4 mechanosignaling pathway that regulates histone modifications and blastema cell remodeling during zebrafish heart regeneration.

The paper analyzes viral diversity in deep sea cold seep sediments, finding high endemism and links to microbial hosts and biogeochemical cycling.

This study induces bipedal posture in mice to create a model of lumbar ligamentum flavum hypertrophy and shows increased stress leads to degeneration.

The paper measures physical properties of mouse meiotic prophase I chromosomes, finding they are stiffer than mitotic chromosomes and have a gel-like chromatin organization.

This study shows SARS-CoV-2 uses the SR-B1-mediated HDL uptake pathway alongside ACE2 for entry, and blocking this pathway inhibits infection.

This study examines T cell immunity in UK COVID-19 patients, finding stronger and broader memory T cell responses in severe cases, with implications for vaccine design.

The paper examines the expression of SARS-CoV-2-related molecules in human tissues and immune cells across health and disease states, identifying age, comorbidities, and immune cell types associated with altered expression.

This study identifies increased p53 signaling as the cause of impaired neural differentiation in HUWE1-promoted XLIDs, showing that reducing p53 levels rescues neurodevelopmental defects.

This study shows prohibitin protects human pulmonary microvascular endothelial cells from cigarette smoke extract-induced apoptosis by preserving mitochondrial function and reducing oxidative stress.

This study shows that deficiency in ER acetyl-CoA import via AT-1 in acinar cells leads to chronic pancreatitis through ER stress and fibrosis.

The paper analyzes 120 SARS-CoV-2 genomes to identify genetic subgroups, recombination events, and a unique spike protein insertion that may enhance infectivity.

This study shows obesity alters ECM composition in mammary tissue, promoting breast cancer invasion and metastasis through Collagen VI and EGFR signaling.

This paper develops a pipeline to predict ECM protein effects on breast cancer invasion by analyzing cell shape and migration metrics, finding that cell shape better predicts 3D invasion than 2D migration.

This study identifies a novel G protein-biased and subtype-selective agonist for the 5-HT2C receptor from herbal extracts, showing efficacy in weight loss similar to lorcaserin.

This paper develops a method to produce human amniotic epithelial cells-only membrane with higher purity and clinical potential for wound healing.