Y. Zhu

This study determines the cryo-EM structure of QUAC1, an R-type anion channel, revealing its dimeric architecture and mechanism of malate-mediated activation.

This study identifies key regions in type III CRISPR-Cas systems for RNA targeting and cOA production, leading to the development of the SCOPE diagnostic tool for SARS-CoV-2 detection.

The paper screens cell-virus and cell-cell interactions across multiple species to identify potential hosts and co-evolution patterns of viruses including SARS-CoV-2.

This study shows Brsk2 amplifies parasympathetic signals to promote type 2 diabetes by enhancing β-cell insulin secretion in obese mice and associates human BRSK2 variants with metabolic disorders.

This study shows that disrupting rRNA biogenesis in mouse embryonic stem cells induces a 2C-like state through reorganization of peri-nucleolar heterochromatin and activation of the 2C program.

The paper investigates how genetic variants in the ACE2 gene affect susceptibility to SARS-CoV-2 infection by analyzing their impact on viral entry.

This study identifies flavonols and dihydroflavonols as potential inhibitors of SARS-CoV-2 and HCoV-229E main protease activity and viral replication.

This study shows that blue light inactivates catalase in bacteria, making them vulnerable to ROS and immune cells, and validates this in a mouse model.

This study constructs high-resolution spatial transcriptomes of primary liver cancers to analyze spatial architecture and identify tumor microenvironment features.

This paper investigates the structure-function relationship of PfAtg8, a divergent Atg8 protein in malaria parasites, showing that its non-autophagic function in apicoplast inheritance does not rely on canonical Atg8 interaction domains.

The paper identifies a novel lineage of SARS-related coronaviruses from bats that use bat ACE2 receptor but not human ACE2, suggesting potential zoonotic risks.

The paper reports crystal and cryo-EM structures of human CCKAR and CCKBR with ligands, revealing ligand recognition and activation mechanisms.

This study shows that Pseudomonas aeruginosa induces acute lung injury in mice through its LasB protease, causing hemorrhagic diffuse alveolar damage and hyaline membranes.

This study develops an IFN-armed RBD dimer vaccine that induces strong neutralizing antibodies and T cell responses, offering complete protection against SARS-CoV-2 in rhesus macaques with a single dose.

This study identifies ACE2 as a marker of immuno-hot tumors in breast cancer by analyzing its expression and correlation with immune features across multiple datasets.

This study shows high arsenic levels increase transcriptional activity of arsenic metabolism genes in paddy soils without significantly affecting their diversity or abundance.

This study identifies METTL9 as a tumor-promoting methyltransferase that methylates zinc transporters, disrupting zinc homeostasis and promoting cancer growth.

This paper develops a non-hormonal contraceptive method using a hexavalent sperm-binding antibody delivered via a dissolving vaginal film, showing potent sperm inhibition in sheep.

This paper shows that palmitic acid induces autophagy in NAFLD neutrophils, leading to granule degradation and reduced adhesion, impairing neutrophil function.

This paper identifies a protein-priming mechanism for SARS-CoV RNA synthesis and shows that AT-527 inhibits this process by targeting both NiRAN and RdRp domains.

This study examines the kinetic response of B-cell receptor (BCR) repertoire diversity and lineage expansion in non-human primates after TLR7/8 stimulation, finding that TLR7/8 selectively expands high-mutation, low-frequency IgKL lineages.

The paper compares SARS-CoV-2 replication in pediatric and adult nasal epithelial cells, finding lower viral titers in children for ancestral and Delta variants, but higher replication for Omicron.

A natural allele of rice UMP1 promotes resistance to multiple pathogens by boosting H2O2 accumulation.

The fungal pathogen Ustilaginoidea virens disarms chitin-triggered immunity in rice flower via a secreted chitinase, revealing a mechanism of disease susceptibility.

This study uses native top-down mass spectrometry to characterize O-glycoforms of the SARS-CoV-2 S-RBD, identifying seven glycoforms and their relative abundance.

This study shows that elaborated feedback during instructor-learner interactions enhances learning transfer and is associated with neural synchronization in frontoparietal regions.

This paper develops protease-resistant lipopeptides to inhibit HPIV3 infection by modifying the HRC domain, showing improved in vivo stability and antiviral activity in animals.

This study evaluates enzalutamide's antiviral efficacy against SARS-CoV-2 in different cell types and mouse models, finding it effective in prostate cancer cells but not in lung cells or organoids.