H. Li

This study engineers AAV vectors for acoustically targeted gene delivery, improving specificity and efficiency while reducing peripheral transduction.

This study classifies wheat WAKs and WAKLs, identifies structural features, and shows that TaWAK75 and TaWAK76b are involved in resistance to Bgt.

This study shows TGFβ2 increases HTM cell contractility via ERK and ROCK pathways, with distinct crosstalk depending on the culture substrate.

The paper identifies RNA editing of the BOSS gene in tomato that regulates flowering by producing functionally distinct transcripts.

This study shows that inhibiting mechanosensitive channels reduces TGFβ2-induced actin remodeling and reactivity in optic nerve head astrocytes.

This study compares the structural differences between a pseudouridine-modified and pseudouridine-free ribosome, showing how the absence of pseudouridine affects inter-subunit movements and translation efficiency.

This study identifies genomic changes and novel toxins in Liberibacter pathogens through comparative phylogenomic analysis, linking prophage loci and gene gains/losses to pathogenicity.

This study identifies a type VI secretion system in Acidovorax citrulli that can breach gram-positive and fungal cell envelopes, with RhsB as a key effector.

This study reveals the structural basis of SETD2 methyltransferase interaction with hnRNP L paralogs, showing how a leucine pair in SETD2 interacts with hnRNP L RRM2 and affects splicing regulation.

This paper develops a protein hydrogel that mimics articular cartilage by combining physical entanglements and force-induced unfolding, achieving mechanical properties comparable to natural cartilage.

The paper infers a population super bottleneck in African humans around 930-813 thousand years ago using genomic data and the FitCoal method.

This study identifies the roles of histone acetyltransferases and deacetylases in the growth, virulence, stress resistance, and DNA repair of Alternaria alternata through gene deletion mutants.

This study shows a single intranasal vaccination with inactivated Acinetobacter baumannii rapidly protects mice against pneumonia by training alveolar macrophages, with effects observed against other Gram-negative bacteria but not Gram-positive ones.

The paper identifies glucose and amino acid contributions to hepatic de novo lipogenesis and steatosis in obesity using metabolic tracing and in vivo studies.

Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.

This study identifies two non-coding A-to-T mutations at the Kozak site of the N gene as potentially contributing to the transmissibility of Alpha, Delta, and Omicron SARS-CoV-2 variants.

This study reports the first structure of a P4B ATPase, Neo1, and shows it uses a conserved mechanism for substrate transport similar to dimeric flippases.

This study shows that Cdc42 GTPase activity and its regulation by Bud8 and Rga1 influence replicative lifespan in budding yeast through effects on cell polarity and division symmetry.

This paper isolates and characterizes a quinclorac-degrading bacterium, Cellulosimicrobium cellulans sp., showing 45.9% degradation efficiency and identifying two novel degradation products.

This study identifies the DEPDC1-EEF1A1-FOXO3a axis as a critical pathway promoting osteosarcoma progression by downregulating FOXO3a, with implications for therapeutic strategies.

This paper discovers CIPS nanosheets that selectively bind SARS-CoV-2 spike protein, inhibit viral entry, and promote macrophage-mediated viral elimination.

This study identifies unbalanced dietary patterns as contributors to precocious puberty by altering gut microbiota and host metabolites, with biomarkers showing high diagnostic accuracy.

The paper uses a pooled screening approach to identify genomic factors influencing nanoparticle-cell interactions and validates biomarkers for nanoparticle uptake.

This study shows that both increased and decreased SUMOylation enhance drought tolerance in apple by modulating MdDREB2A stability through SUMOylation and ubiquitination.

This study identifies that SARS-CoV-2 nucleocapsid protein undergoes phase separation, which can be modulated by small molecules, offering new therapeutic strategies against COVID-19.

This paper reports the isolation and identification of Bergeyella zoohelcum from a cat-bite infected child, highlighting challenges in its detection and the importance of advanced techniques.

Overexpression of VDAL in Arabidopsis enhances resistance to Verticillium dahliae by preventing degradation of the transcription factor MYB6 through interaction with PUB25/26 E3 ligases.

The paper identifies and characterizes sequence motifs and ion selectivity mechanisms in channelrhodopsins from diverse algal and protist species using electrophysiological analysis and genomic data.