H. Li

The paper constructs phylogenetic trees using 8-mer motif sets from genome sequences, finding that CG and TA independent selection patterns reflect different evolutionary states in primates and insects.

This paper identifies a conserved BAH module in BAHD1 that reads H3K27me3 and mediates gene silencing by recruiting histone deacetylases, essential for development.

This study uses single-cell transcriptomics to show hyperinsulinemia affects pancreatic cancer development and immune microenvironment by altering immune cell pathways and reducing pre-cancerous lesions.

This paper identifies the molecular mechanism by which SPIN*DOC inhibits Spindlin1's transcriptional coactivator activity through multivalent binding and competitive inhibition.

This paper develops a p-ELISA method using a multiepitope fusion protein to diagnose bovine and goat brucellosis, achieving high sensitivity and specificity.

This study identifies intrinsic cardiac adrenergic cells as contributors to septic cardiomyopathy by releasing norepinephrine that exacerbates cardiac dysfunction through β1-adrenergic receptor activation.

This study identifies additional ORFs in geminiviral genomes that encode small proteins with specific subcellular localizations and virulence functions.

This study identifies PAQR3 as a predictor of epirubicin response in TNBC and shows that MAPK inhibition can reverse resistance caused by miR-138-5p-mediated PAQR3 downregulation.

This study identifies a hypervirulent CRKP strain in Egypt carrying two plasmids with carbapenemase and virulence genes, highlighting the genetic basis of resistance and virulence.

This study compares the metabolic profiles of sweet potato leaves grown in soil versus hydroponic systems to identify metabolites associated with taste quality differences.

The paper identifies accelerated evolution in the Nrk gene's exons in eutherian mammals, suggesting a new exon ignited positive selection linked to placental development.

This paper introduces a machine learning method to predict cellular forces from microscope images by training on wrinkle patterns and traction force data.

This study shows that MMP12 knockout prevents weight and muscle loss in ApcMin/+ mice with cancer cachexia by disrupting insulin and glycolipid metabolism.

The paper structures and functionally characterizes an in vivo assembled Type III-A CRISPR-Cas complex, revealing how RNA binding controls its enzymatic activity through protein dynamics.

This paper demonstrates that SHIVs with bulky aromatic amino acid substitutions at Env375 replicate efficiently in rhesus macaques and can be used for preclinical HIV vaccine testing.

This study identifies the ZmCd1 gene controlling cadmium accumulation in maize grains and develops molecular markers for breeding low-Cd maize varieties.

This study identifies the structural and molecular mechanisms of two neutralizing antibodies against FMDV, showing they disrupt virus-receptor interactions and provide prophylactic and therapeutic benefits.

The paper reports the crystal structure of bromide-bound GtACR1, showing structural changes that relax constrictions in the anion tunnel, indicating a transition to a pre-activated state.

This study elucidates the mechanism of +1-frameshifting by tRNA SufB2, showing it uses triplet-slippage and ribosome conformational changes to decode quadruplet codons for genome recoding.

The paper identifies proinflammatory gut microbiome features in SLE patients through metagenomic analysis and shows potential autoimmunogenic mechanisms.

Squid provides an affordable, open-source imaging platform with modular hardware and software for deploying advanced microscopy techniques in research and low-resource settings.

This study shows that PARPi treatment can reverse RAD51C promoter methylation and restore expression in a high-grade serous ovarian cancer model, while maintaining platinum sensitivity.

The paper determines cryo-EM structures of the activated PapC usher during P pilus biogenesis, revealing processive steps and conformational dynamics.

This study investigates how HIV-1 Env is recruited and retained at the virological synapse through targeted recycling rather than irreversible interactions.

The paper introduces REPOST, a framework predicting potential virus hosts by analyzing receptor orthologs, achieving 95.74% accuracy for SARS-CoV-2.

This study shows that disrupting FGF2 enhances thermogenesis in brown and beige fat, reducing obesity and hepatic steatosis in mice.

This study develops and tests a recombinant RBD-Fc vaccine against SARS-CoV-2, showing protection in non-human primates and mice.

This study investigates how salicylate, bile acids, and extreme acid affect the fitness of multidrug efflux pumps in E. coli, revealing tradeoffs and conditions under which these pumps confer advantages or costs.

The paper identifies STAT3 as an inhibitor of Myocardin-mediated cardiac hypertrophy by directly binding to Myocardin and suppressing its transcriptional activity.

This study evaluates the cytotoxicity of chloroquine and hydroxychloroquine in multiple cell lines and tissues using a dynamic imaging system and PBPK model, finding HCQ less toxic than CQ in most cases.