H. Yang

This paper introduces a quantitative framework to describe integrated watershed ecosystems by analyzing flow networks and holistic properties across geomorphic, hydrological, ecological, and socio-economic dimensions.

This study uses single-cell transcriptomics to identify novel cell populations and functional differences in human nucleus pulposus during degeneration, revealing potential regenerative and immunosuppressive roles.

This study identifies Coproheme Decarboxylase (ChdC) as a regulator of heme synthesis and uptake in Mycobacterium tuberculosis, showing it controls heme bioavailability and iron acquisition in response to iron availability.

The paper identifies immune microenvironment subtypes in follicular lymphoma linked to tumor mutations and antigen expression, informing potential immunotherapeutic strategies.

This paper develops a neural network energy function for protein physics using unsupervised learning on 3D local structures, showing it can recognize patterns in protein structures.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

The paper uses cryo-electron microscopy to visualize mitoribosome biogenesis, showing how GTPBP7 and NSUN4/MTERF4 regulate PTC formation and mitochondrial function.

This study identifies a novel inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives through crystallography and mass spectrometry, revealing a unique covalent adduct formation and by-product generation.

This study models the future distribution of Rift Valley fever in East Africa under climate change scenarios using MaxEnt, identifying key environmental factors and predicting expanded disease spread.

The paper compares metatranscriptomic responses of Arabidopsis to endophytic and pathogenic Fusarium strains, revealing transcriptional plasticity and differential gene regulation.

This study shows SARS-CoV-2 entry into host cells relies on clathrin-mediated endocytosis and phosphoinositides, with ACE2's cytoplasmic domain and enzymatic activity not required for this process.

This study shows that RIPK3 phosphorylation at S165/T166 switches its function from necroptosis to apoptosis, driving corpus luteum regression via PGF2-induced apoptosis.

The paper develops an RNA editing signature (GCRE) to predict chemotherapy response in gastric cancer, achieving 84% accuracy and showing better outcomes in patients with higher editing levels.

This study analyzes H7N9 virus genome mutations in human clinical samples to identify potential adaptations during infection.

The paper demonstrates that HLA-E restricted, HIV-1 specific CD8+ T cells can suppress HIV-1 replication in vitro, suggesting potential for a universal vaccine.

The study analyzes the urinary microbiota of 147 Chinese women, revealing non-sterile urine with distinct bacterial communities and showing similarity to cervical and uterine microbiota rather than vaginal microbiota.

This study uses single-cell RNA-sequencing to analyze prostate cancer tumor microenvironment, identifying heterogeneous epithelial cell states and tumor-associated club cells.

The paper shows that knocking down LC3 increases micronuclei by promoting mitochondria-to-micronuclei transition during nuclear development.

This paper identifies a mammalian-unique eIF4E2-GSK3β pathway that prevents senescence and protects against hypoxia by maintaining p53 phosphorylation.

This study shows arachidonic acid metabolism regulates macrophage polarization by affecting oxidative phosphorylation through PPARG, influencing M1 and M2 macrophage activation.

This study synthesizes and characterizes SR-A3, a stereoisomer of a natural product, showing enhanced binding kinetics and therapeutic efficacy in a mouse lymphoma model.

The paper shows mitochondria fragment and reassemble to form nuclei and intranuclear inclusions during nuclear development.

This study shows telmisartan enhances insulin secretion via ion channels, independent of AT1 receptor and PPARγ, in rat islets and diabetic mice.

This study identifies cadherin-11 as a mediator of cancer cell hijacking of fibroblasts post-EMT, enhancing invasion and metastasis in solid tumors.

This study shows SARS-CoV-2 uses the SR-B1-mediated HDL uptake pathway alongside ACE2 for entry, and blocking this pathway inhibits infection.

This study examines the effects of different dietary protein levels on ewe growth, serum biochemistry, and lamb development during late pregnancy, finding no significant impact on growth performance but significant effects on metabolic indicators and lamb body measurements.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

This paper shows HCMV drives WDR5 to the virion assembly compartment to facilitate virion assembly, expanding its role beyond nuclear egress.

This study identifies site-specific O-glycosylation patterns in SARS-CoV-2 spike proteins, revealing host-dependent variations and their potential implications for viral function and therapeutic development.