J. Chen

This study investigates how substrate recognition modulates strigolactone receptor selectivity in witchweed using molecular dynamics simulations and structural analysis.

This study identifies parasite variant surface antigens that help Plasmodium falciparum evade immune clearance in vivo using a humanized mouse model.

The paper identifies five ABCB transporters that regulate lateral root spacing in Arabidopsis by modulating auxin oscillation amplitude in outer root tissues.

This study shows that metformin chlorination byproducts are toxic to nematodes, human cells, and mice, and identifies boiling and activated carbon as effective removal methods.

This paper describes a catalase-based therapeutic for COVID-19 that reduces oxidative stress and cytokine production in human and animal models without toxicity.

This study analyzes S:A ratios across species to understand dosage compensation mechanisms in sex chromosomes, finding clade-specific patterns and supporting the sex chromosome insensitivity hypothesis.

This study shows that a recombinant SARS-CoV-2 S1-Fc fusion protein induces strong neutralizing antibodies in nonhuman primates and can be produced at scale for vaccine development.

The paper shows that disrupting cell cycle checkpoints can restore DNA damage-induced inflammation and anti-tumor immune responses in cancer cells.

The paper identifies 54% of human PH domain-containing proteins as having PIP binding affinity, using single-molecule pulldown assays and a recursive-learning algorithm.

This study shows the D614G mutation in SARS-CoV-2 spike protein increases viral infectivity and is more susceptible to elastase cleavage, with minimal impact on neutralizing antibody efficacy.

This study shows that combining controlled-release urea with 300 kg ha-1 potassium chloride improves soil fertility, plant growth, and yield of Italian ryegrass.

This study shows that increasing crop diversity enhances biomass but reduces seed yield due to lower reproductive effort in mixtures compared to monocultures.

This study compares CRISPR/Cas endonucleases for in vivo retinal gene editing and finds SpCas9 delivered via AAV7m8 achieves the highest knockout efficacy.

This study finds a strong correlation between anti-RBD and anti-ECD IgG titers and in vitro virus neutralization titers in convalescent plasma, suggesting these titers can serve as surrogates for neutralizing activity.

The paper shows iron supplementation eliminates antagonistic interactions between root-associated bacteria by revealing iron limitation drives these interactions.

This study identifies LILRB3 as a myeloid checkpoint receptor that suppresses immune responses through agonistic monoclonal antibodies, showing immunosuppressive effects in vitro and in humanized mice.

This study evaluates how the radiated brain microenvironment affects the growth of nine human glioblastoma cell lines, finding that some tumors grow faster while others grow slower in this environment.

This study uses single-cell RNA sequencing to analyze gastric cancer tumor microenvironment, identifying reprogramming in immune and stromal cells and novel molecular targets for immunotherapy.

This study identifies the tumor cell proteome of pancreatic cancer in vivo using BONCAT and DIA-MS, distinguishing it from non-tumor cells in the tumor microenvironment.

This study shows that microbubble-mediated cavitation induces apoptosis and reduces invasion in AsPC-1 cancer cells through increased calcium, cleaved Caspase-3, BAX, and decreased Bcl-2, HIF-1, and Vimentin.

This study uses single-cell RNA-seq to analyze keloid tissue and identifies lineage-specific regulatory changes in fibroblasts and vascular endothelial cells, highlighting key pathways and potential therapeutic targets.

This study identifies ARTS as a p53-responsive gene that promotes mitochondrial apoptosis by interacting with p53 and enhancing its pro-apoptotic effects.

This study shows that EphA2 overexpression in NSCLC tumors reduces T cell infiltration and increases myeloid suppressor cells, promoting immune evasion.

This study determines the structure of the mammalian PA28β-iCP immunoproteasome using cryo-EM, revealing a unique mechanism of proteasome activation distinct from constitutive proteasomes.

This study identifies HK2 as a marker for detecting underrepresented CTCs in NSCLC, revealing a distinct subpopulation with unique characteristics.

This study shows that NPM1 regulates macrophage function through rRNA 2'-O-methylation and translation control, revealing a role in immune cell activity.

This study shows that prenatal arsenic exposure in mice leads to transgenerational impairments in spermatogenesis, associated with epigenetic changes in Igf2 and H19.

This paper presents a CAD system for pulmonary nodule detection that improves recall, reduces false positives, and optimizes time consumption using a multi-model ensemble approach.

This paper introduces a reagentless sensor that detects molecular analytes in biological fluids by measuring directional diffusion of a nanoscale molecular pendulum and electron-transfer kinetics.

This paper introduces a new gene-delivery method using magnetic nanoparticles and ultrasound, achieving higher transfection efficiency with lower toxicity than conventional techniques.