L. Xu

This paper proposes a computational method to track multiple fluorescent molecules in a multi-focus confocal setup, enabling 3D high-speed tracking below the diffraction limit.

This study develops autonomous microinjectors for GI delivery of insulin, showing they can deliver insulin systemically at levels comparable to intravenous administration.

The paper shows TIR domains catalyze ADP-ribosylation reactions to produce signaling molecules that specifically activate the EDS1-SAG101-NRG1 immunity branch in plants.

The paper identifies TIR-catalyzed pRib-AMP/ADP as a signaling molecule in plant immunity and shows it binds to the EDS1-PAD4 complex.

The paper shows Belgian endive root extracts promote shoot and root growth in Arabidopsis and Plectranthus, with water-soluble sugars and malate as key bioactive compounds.

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.

The paper shows that neural stemness unifies tumorigenicity and pluripotent differentiation potential by demonstrating SETDB1's role in maintaining these properties through epigenetic and transcriptional mechanisms.

This study investigates how Enterococcus faecium develops resistance to a combination of daptomycin and fosfomycin, finding that resistance mechanisms are largely independent and that fosfomycin resistance involves changes in phosphoenolpyruvate flux.

This paper develops a high-throughput GlyExo-Capture technique to isolate fucosylated extracellular vesicles and identifies a 4-miRNA signature for hepatocellular carcinoma detection.

This paper introduces microbowls with controlled concavity to improve the accuracy and sensitivity of microscale mass spectrometry by concentrating analytes.

This study identifies a potent human monoclonal antibody, 35B5, that neutralizes SARS-CoV-2 and its variants by targeting a conserved epitope on the RBD, offering a potential therapeutic and vaccine design strategy.

This study identifies and characterizes quiescent stem cells in the mammalian esophageal epithelium using scRNA-seq and DNA methylation profiling in rat models.

The paper identifies JAK-STAT signaling as a key driver of lineage plasticity-driven resistance to AR targeted therapy in prostate cancer using integrated transcriptomic and scRNA-Seq analysis.

The paper introduces a method to sense enzyme product formation using host cell metabolism and mass spectrometry to map enzyme activity and mutagenesis effects.

This study shows that proton export drives the Warburg Effect by increasing intracellular alkalization, enhancing glycolytic flux, and promoting cancer aggressiveness.

This paper shows that combining disulfiram and copper(II) gluconate significantly enhances anti-SARS-CoV-2 activity in vitro compared to either compound alone.

This study identifies VGLL2-NCOA2 as an oncogene driving pediatric sarcomagenesis by reactivating developmental programs, with ARF6 overexpression as a potential therapeutic target.

This study shows that SARS-CoV-2 ORF7 increases monocyte chemotaxis via CCL2 and decreases neutrophil recruitment via reduced IL-8.

This study identifies co-infection events of SARS-CoV-2 lineages in genomic data, finding 53 events across 29,993 samples, including one triple lineage infection, and notes an increasing trend with viral diversity.

This study shows that defective desmosomal adhesion causes arrhythmogenic cardiomyopathy through an integrin-αVβ6/TGF-β signaling cascade, leading to fibrosis and arrhythmias.

This study shows that MyD88, not TRIF, is required for DC activation and alloantibody response to stored syngeneic RBCs in mice.

This study identifies three conserved interbacterial antagonism resistance clusters in Pseudomonas aeruginosa that function independently and provide specific defense against phospholipase toxins.

This study shows that OsLEC1 inhibits photosynthesis in rice embryos to promote seed dormancy by regulating hormonal pathways and gene networks.

This study shows that maternal exposure to dibutyl phthalate during pregnancy and lactation leads to increased visceral obesity in adult female offspring without affecting serum glucolipid levels or the PI3K/AKT pathway in muscle.

This paper develops a CRISPR/Cas13a system combined with super resolution imaging for direct, amplification-free viral RNA detection with improved sensitivity.

This study identifies ERAD as a proteostasis checkpoint during β-selection, showing Sel1l deficiency causes ER stress and apoptosis, impairing β T cell development.

This paper refines muscle-invasive bladder cancer classification using multi-omics data, identifying four subtypes with distinct prognoses and therapeutic responses.

This paper develops an intranasal ASO therapy targeting SARS-CoV-2 RNA that effectively prevents viral replication in multiple models and variants.

The paper tests hypotheses about stomatal size-density scaling in plants using macroevolutionary models and phylogenetic regression on 2408 species, finding support for the stomatal-area increase hypothesis for higher gmax.

This study shows that chronic exercise in PCK rats reduces renal cyst growth and dysfunction by modulating specific signaling pathways.