D. Li

This paper introduces a deep learning framework for fast fluorescence lifetime imaging under low-light conditions, achieving robust results with few photons per pixel.

The paper introduces a self-supervised denoising method for structured illumination microscopy that enables high-quality super-resolution imaging with reduced fluorescence.

This study investigates the effects of bovine milk-derived exosomes on human skin anti-aging, showing they enhance moisture retention and reduce wrinkles while being safe for use.

This study shows that striatal astrocytes regulate behavioral flexibility and metabolism in obesity through chemogenetic manipulation in mice.

This study shows Lactococcus G423 improves broiler growth and survival by altering gut microbiota and metabolites, while antibiotics negatively affect microbiota.

The paper develops an mRNA vaccine to predict brain tumor response to checkpoint inhibitors by analyzing cytokine release patterns in vitro.

This paper introduces Alpha-LFM, a physics-aware deep learning framework for 3D super-resolution imaging of living cells, achieving high resolution, speed, and low phototoxicity over long periods.

This paper introduces a zero-shot deep learning method for super-resolution microscopy that enhances resolution with less fluorescence and no training data.

This study assesses neutralization of SARS-CoV-2 Omicron subvariants by sera from different vaccination and breakthrough infection cohorts, finding that BQ.1.1 and XBB.1.5 show strong neutralization evasion.

This study shows vaccinia virus induces EMT-like changes and RhoA-mediated mesenchymal migration in epithelial cells, facilitating viral spread.

This study shows that doramectin promotes CD8+ T-cell metabolic reprogramming and antitumor immunity, mediated by gut microbiota interactions.

This study identifies and characterizes SA09310 as a novel tetracycline resistance efflux pump in Staphylococcus aureus, showing it mediates drug resistance through H+-dependent extrusion.

The paper uses metagenomics to identify 22 RNA viruses in ticks from northeastern China, revealing novel species and highlighting public health risks from emerging tick-borne viruses.

The paper identifies a new CRISPR-Cas12l system from metagenomes, showing it cleaves DNA with a unique PAM and forms a bracelet structure for gene editing.

This study shows zebrafish embryos are more efficient and robust than larvae for evaluating human norovirus infectivity, enabling virus passaging and UV inactivation testing.

This paper introduces a soft, stretchable organic bioelectronic system for continuous intra-operative neurophysiological monitoring during microsurgery, demonstrating improved signal quality and reduced post-operative complications in animal models.

This study identifies a signaling cascade involving GxcM, Fbp17, RacC, and WASP that regulates rear cortical actin assembly in migrating Dictyostelium cells.

The paper identifies a proliferative exhausted CD8+ T cell cluster in HPV-positive HNSCC that correlates with better patient survival and suggests potential therapeutic implications.

This study shows a nanoparticle vaccine induces broad neutralizing antibodies against multiple SARS-CoV-2 variants and protects non-human primates and mice from viral challenges.

The paper analyzes sex differential genes across seven tissues in BXD mouse strains, revealing organ- and chromosome-dependent expression patterns and functional roles.

The paper investigates the role of DnaA-ATP/ADP conversion in E. coli replication initiation, finding that intrinsic ATPase activity alone can maintain robust initiation, with regulatory elements enhancing stability during multifork replication.

This study identifies two broadly neutralizing antibodies against SARS-CoV-2 variants and shows their synergistic neutralization effect, supported by cryo-EM structures.

The paper shows that embryonic vitamin D deficiency in HSCs leads to diabetes in mice by altering epigenetic pathways and macrophage function.

The paper examines how soil depth influences microbial community structure and enzymatic activity in extreme desert environments, finding that depth-related environmental heterogeneity drives these patterns.

This paper engineers a precise adenine base editor, ABE9, with reduced bystander mutations and off-target effects, enabling efficient and accurate A-to-G editing in mouse and rat embryos.

This study shows that cell surface excess (CSE) is crucial for protrusions and motility in 3D collagen matrices, with microtubules regulating its storage and release.

This study identifies how coronaviruses like PEDV and SARS-CoV-2 evade antiviral responses by manipulating caspase-1 and inhibiting IFN-I signaling through proteolytic activities.

The paper examines how fat accumulation in livers with simple steatosis affects liver stiffness, finding that fat softens the liver locally rather than uniformly.

REST is a deep learning method that restores cryo-ET density maps by denoising and compensating for missing wedge effects, enabling visualization of individual macromolecules.

This study evaluates the toxicological effects of flavored oral nicotine pouches on lung epithelial cells, finding increased cytotoxicity, ROS production, and cytokine release.