D. Li

This study shows that overexpressing connexin43 in bone marrow-derived stromal stem cells promotes osteogenesis and angiogenesis, enhancing bone regeneration in a rat model of glucocorticoid-induced osteonecrosis.

The paper compares cryo-EM structures of SARS-CoV-2 Omicron and Delta spikes to analyze conformational changes affecting immune evasion and transmissibility.

This paper identifies synthetic lethality between PRC2 inactivation and DNMT1 inhibition in MPNST, showing enhanced cytotoxicity through retrotransposon activation and innate immune signaling.

This study shows Hsp27 binds phosphorylated Tau to prevent its aggregation and mitigate AD pathology.

This study uses cryo-electron tomography to analyze autophagosome formation in yeast, revealing membrane shape transitions and interactions during biogenesis.

The paper identifies maternal and embryonic signaling-driven differentiation of luminal epithelial cells in the mouse endometrium and shows conservation in humans.

The paper uses proteomics to analyze PTM changes in HIV-1-infected cells, identifying mechanisms of host pathway remodeling through Aurora kinase A and PP2A modulation.

This study analyzes genetic diversity of Candidatus Liberibacter asiaticus in China using hypervariable genomic regions to understand strain differences and inform HLB control strategies.

This study shows hyperuricemia induces renal tubular epithelial pyroptosis via ROS-mediated NLRP3 inflammasome activation in cultured cells and rat models.

This study shows that tyrosine phosphorylation modulates TRPV2's chemical and thermal sensitivity in macrophages through JAK1 and PTPN1.

The paper develops a method to rapidly quantify PHA in living cells using GFP-labeled phasins, achieving high accuracy with R-squares over 0.9.

This study shows that hypothalamic astrocytes regulate systemic glucose metabolism and energy balance through extra-synaptic glutamate signaling, offering new targets for obesity treatment.

This study investigates how synovial fluid properties affect Staphylococcus aureus aggregation and identifies polymer bridging as a mechanism, with implications for post-surgical joint infections.

This study identifies the intestine as the primary source of circulating TCA cycle intermediates in mice, showing endogenous production exceeds microbial contributions.

This paper develops first-in-class PROTACs that selectively degrade cytosolic sEH, reducing ER stress more effectively than sEH inhibitors.

This paper identifies a broadly neutralizing antibody, STI-9167, effective against SARS-CoV-2 variants including Omicron and Omicron + R346K, and describes its development for clinical trials.

This paper introduces a topological supramolecular network strategy to create highly conductive and stretchable organic bioelectronics with unprecedented performance in physiological environments.

This study uses single-cell RNA sequencing to analyze cardiac immune cell dynamics after myocardial infarction in mice, identifying key immune subsets and their roles in disease progression.

This paper shows that a G358S mutation in PfATP4 confers clinically relevant resistance to cipargamin and (+)-SJ733 in P. falciparum parasites.

The paper shows that BSMV γb protein targets NbTRXh1 to reduce its reductase activity, impairing SA defense gene expression and enhancing viral movement.

This paper demonstrates that non-T-cell based antigen depletion can induce apoptosis in CD19-expressing cancer cells, proposing a universal cellular therapy strategy using artificial antigen-recognizing cells.

This study shows that ALA-PDT kills drug-resistant M. marinum in vitro and in a mouse model, leading to recovery of cutaneous lesions and clinical improvement in two patients.

The paper tests neutralization activity of sera from convalescents and vaccine recipients against Omicron, finding that vaccines maintain better neutralization than convalescents.

The paper determines the cryo-EM structure of human SOD1 amyloid fibrils, revealing conformational changes associated with ALS pathology.

This study identifies circRNA expression patterns in healing and non-healing wounds and finds two circRNAs that impair keratinocyte migration while promoting proliferation in non-healing venous ulcers.

This study shows host casein kinase 1 phosphorylates a viral phosphoprotein, altering its phase separation and affecting virus infection.

This study compares alpha-synuclein fibril structures from preclinical and postmortem Parkinson's disease patients, showing structural and pathological differences in fibril conformation during disease progression.

The paper isolates two camel nanobodies that broadly neutralize SARS-CoV-2 and its variants, showing therapeutic potential in mice.

The paper reviews marine microbiome studies, analyzes 17.59 Tb of sequencing data, and constructs genome and gene catalogues to explore marine prokaryotic diversity and function.