S. Zhao

This study identifies LRRC23 as a conserved component of the radial spoke complex in mouse sperm, essential for flagellar motility and male fertility but not ciliary function.

The paper develops a minimal-invasive neural interface using MXene nanosheets to promote nerve regeneration and electrophysiology recording in mice.

This paper shows that combining disulfiram and copper(II) gluconate significantly enhances anti-SARS-CoV-2 activity in vitro compared to either compound alone.

This paper introduces a cyborg brain organoid platform for long-term 3D electrophysiological recording, enabling continuous monitoring of single-cell action potentials during brain organoid development.

The paper reports crystal and cryo-EM structures of human CCKAR and CCKBR with ligands, revealing ligand recognition and activation mechanisms.

The paper identifies a new ERGIC-ERES membrane contact mediated by TMED9 and SEC12 that is essential for autophagosome biogenesis under stress.

This study develops an AAV-ie-S1 vaccine that neutralizes SARS-CoV-2 variants B.1.1.7 and B.1.351, offering protection against emerging strains.

This study identifies endophilin A1 as a calmodulin effector that drives dendritic spine enlargement via actin polymerization during LTP induction.

This study shows that both increased and decreased SUMOylation enhance drought tolerance in apple by modulating MdDREB2A stability through SUMOylation and ubiquitination.

This study identifies additional ORFs in geminiviral genomes that encode small proteins with specific subcellular localizations and virulence functions.

The paper uses molecular dynamics simulations to study Piezo1 channel opening and identifies a multi-fenestrated ion permeation pathway.

This study shows that adiponectin improves healthspan and lifespan by enhancing insulin sensitivity and reducing age-related metabolic and inflammatory disorders in mice.

Microbe-seq enables strain-resolved genome reconstruction from complex microbial communities, revealing intra-phylum horizontal gene transfer and bacteriophage-bacterial associations in the human gut.

This paper introduces a surface-coating technique to improve DNA sequencing speed, cost, and throughput for genomic applications.

This paper develops data-informed strategies to design hydrolytic nanozymes with enhanced catalytic activity and broad substrate specificity.

The paper evaluates a PKC inhibitor in a T2D rat model, finding it halts renal decline indirectly via reduced hyperphagia and directly lowers adiposity.

This study compares nitrogen dynamics in maize-soil systems with urea and urea-straw treatments, finding that straw enhances nitrogen availability through rhizosphere interactions.

This study shows that combining CDK4/6 and HSP90 inhibitors reduces HIF1 expression and cancer cell viability, including in Rb-deficient cells.

The paper introduces SILEC-SF, a method for sub-cellular metabolomic analysis, and finds distinct nuclear acyl-CoA profiles with notable propionyl-CoA enrichment and a new metabolic pathway for histone propionylation.

This study shows hESCs-derived lung organoids can reconstruct human airway epithelium in vivo, with CD47high cells enhancing ciliated cell generation and epithelial thickness.

The paper analyzes canine cancer mutation rates across breeds and cancer types, finding a positive correlation with TP53 mutations and a breed-specific mutation signature in Golden Retrievers.

This study introduces a statistical method to analyze mutation dynamics in influenza A H3N2, showing regional mutation contributions to global epidemics and identifying key amino acids for therapeutic targets.

This paper develops a high-accuracy multiplexed SARS-CoV-2 antibody assay using a nano-plasmonic platform, showing high specificity and sensitivity in serum and saliva samples.

This study develops a non-infectious murine model to study SARS-CoV-2-induced ARDS and CSS, and identifies potential therapeutic agents that alleviate inflammatory symptoms.

This study investigates tree shrew susceptibility to SARS-CoV-2 infection and finds that they show mild symptoms and low viral replication, suggesting limited susceptibility.

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.

This study produces and tests an F(ab')2 fragment against SARS-CoV-2 RBD, showing potent in vitro neutralization with an EC50 of 0.07 g/ml.

The paper presents a molecular typing method for respiratory adenoviruses using universal PCR and sequencing primers for three capsid genes, enabling rapid identification of HAdV types and recombinants in clinical samples.