Y. Cui

This study identifies stage-specific microbial and metabolic changes in RA progression using multi-omics data from a cohort of patients.

This study identifies FAM84B amplification as a marker of poor prognosis in ESCC and shows it promotes cell proliferation by interacting with NPM1 to suppress CDKN2A.

This study shows that homologous or heterologous boosters of inactivated vaccines increase neutralizing antibodies against SARS-CoV-2 Omicron, reducing escape from neutralization.

This study shows that adding a C-terminal tail to the tailless murine GnRHR impairs fertility by reducing FSH production and ovarian follicle development.

This study identifies a type VI secretion system in Acidovorax citrulli that can breach gram-positive and fungal cell envelopes, with RhsB as a key effector.

This study identifies miR-2 as a regulator of Caspase 2 in mud crabs, showing it suppresses WSSV infection through apoptosis induction.

The paper synthesizes genomic, historical, and ecological data to argue that Yersinia pestis entered Europe multiple times during the Second Plague Pandemic, supporting repeated introductions from Asia.

This study identifies SINEs as inhibitors of CRISPR-Cas9 activity by blocking Cas9 mRNA nuclear export, enhancing genome and base editing specificity in human cells.

The paper identifies a suppressor mutation that compensates for SRP loss by slowing translation and reducing fidelity, allowing correct protein targeting in E. coli.

The paper develops macrocyclic peptides that inhibit, stabilize, and probe the Retromer complex's function, showing high affinity and specificity for different subunits.

A mouse-adapted SARS-CoV-2 strain with RBD mutations caused 100% mortality in aged male BALB/c mice and showed altered receptor binding affinity.

This study shows that overexpressing purple acid phosphatase 2 in chloroplasts and mitochondria improves ATP production, plant growth, and seed yield by balancing reducing equivalents and enhancing photosynthesis.

This study shows that myogenic vasoconstriction in mice depends on Gq/11 signaling through AT1aR, not β-arrestin-mediated pathways.

The paper identifies azetidine derivatives that kill Mycobacterium tuberculosis without resistance by inhibiting mycolate assembly, showing a novel mode of action and favorable pharmacological profiles.

This paper discovers a molecular glue, HQ461, that promotes CDK12-DDB1 interaction, leading to Cyclin K degradation and cell death.

This paper develops a novel mouse model for SARS-CoV-2 infection and evaluates the protective efficacy of an RBD-based subunit vaccine.

The paper identifies metabolic subtypes of colorectal cancer using metabolomics and finds correlations between these subtypes and clinical outcomes.

This study shows P4HA2 is overexpressed in glioma and promotes cancer progression by enhancing proliferation, invasion, migration, and EMT, while also regulating the PI3K/AKT pathway through collagen expression.

The paper identifies coadapted genetic elements in Vibrio parahaemolyticus through genome-wide screening, revealing complex interactions and ecological strategies.

The paper introduces a Ponceau S staining dot-blots assay for reliable, fast, and cost-effective protein quantification, reducing costs compared to BCA kits.

The paper identifies PHF19 as a marker of aggressive multiple myeloma and shows a simple four-feature model performs as well as complex gene expression models.

This study identifies three PI(4,5)P2 binding sites on ANO1 that allosterically regulate its Ca2+-activated Cl- channel gating through molecular dynamics and electrophysiology.

This study shows CD155/CD96 promotes immunosuppression in LUAD by inhibiting antitumor immune responses and up-regulating CD96 in CD8 T cells, with potential therapeutic implications.

This study shows that TIGIT-Ig treatment delays lupus onset, reduces autoantibodies, and improves survival in mice, suggesting potential for human autoimmune disease therapy.

The paper identifies epigenetic drivers of esophageal squamous cell carcinoma through multi-omics analysis, revealing hypomethylation patterns and non-canonical WNT signaling activation.

This study characterizes PsBCAT, a branched-chain amino acid aminotransferase from Pseudomonas sp., showing broad substrate specificity and high activity, and demonstrates its application in efficient chiral amino acid synthesis.

This study identifies novel and validated QTLs for fiber quality traits in Upland cotton using a paternal backcross population and RILs, with some QTLs explaining over 10% of phenotypic variation.

The paper analyzes genomic data from 1,103 Vibrio parahaemolyticus isolates to show recent genetic mixing among four populations due to increased human-mediated dispersal.