Y. Zhou

The paper creates a single-cell atlas of colorectal pre-cancerous polyps, identifying distinct molecular programs in adenomas and sessile serrated lesions and their associations with CRC subtypes.

This study extracts and purifies β-2,7,11-cembratriene-4,6-diol from tobacco leaves and demonstrates its antiviral activity against TMV through in vivo and molecular assays.

This study identifies Nrf2/FAM134B-mediated ER-phagy as a protective mechanism against oxidative damage in intervertebral disc degeneration.

This study evaluates AI-based protein structure prediction for NLRP3, showing that AI models can generate reliable structures useful for small-molecule drug discovery.

This study identifies lactoferrin, MUC1, and α-lactalbumin in human breastmilk as antiviral components that inhibit SARS-CoV-2 infection and replication, including variants.

This study develops an in vitro model of SARS-CoV-2 infection in placental cells using iTSCs, showing that syncytiotrophoblasts are infected and that ACE2 inhibition prevents infection and restores function.

This study identifies DDX18 as a negative regulator of IRF3 binding to the IFN-β promoter, suppressing type I IFN production during viral infection.

The paper reveals TACAN is a homodimer with lipid-associated domains and suggests membrane lipids coordinate with the protein to sense mechanical signals.

This study investigates how grafting affects anthocyanin synthesis in grapevines by analyzing metabolomic and transcriptomic profiles across different grafting conditions.

This study identifies chloroplast-extrahaustorial membrane contact sites that regulate callose deposition during plant immune responses to pathogens.

This paper shows metformin reduces anxiety and depression-like symptoms in mice during methamphetamine withdrawal by modulating gut microbiota-derived inosine.

The paper develops a cell-adaptable hydrogel with stem cells to improve spinal cord injury repair by reducing neuroinflammation and enhancing axonal growth in rats.

This paper develops an anti-HLA-A2 CAR for Tregs to induce transplant tolerance, showing they target HLA-A2-expressing grafts and suppress immune rejection.

This paper develops a tunable bioink using collagen and hyaluronan with thixotropic properties and modular ECM components to support multiple tissue types in 3D bioprinting.

The paper identifies horizontal mitochondrial transfer from astrocytes to glioblastoma cells as a mechanism that enhances tumorigenicity by improving mitochondrial function and metabolic capacity.

This study shows L-citrulline reduces hypertension, improves placental function, and fetal growth in a rat model of preeclampsia.

This study demonstrates retron editing enables efficient precise genome editing in human cells without exogenous donor DNA, achieving up to 10% editing rates at endogenous loci.

This study shows Brsk2 amplifies parasympathetic signals to promote type 2 diabetes by enhancing β-cell insulin secretion in obese mice and associates human BRSK2 variants with metabolic disorders.

This study shows that increasing sunflower crop area and supplementing honey bees with sunflower pollen reduces Varroa destructor mite infestation.

This study identifies ribosomal protein L23 as a driver of hepatocellular carcinoma metastasis by upregulating MMP9 expression and promoting tumor growth and metastasis in vivo.

The paper identifies non-reproducible antibody-antigen interactions in clinical sera and develops a model to explain them, improving serological testing for viral infections like COVID-19.

This study isolates and characterizes two nanobodies against SARS-CoV-2 that neutralize the virus through distinct mechanisms, with one showing efficacy against the Alpha variant and reduced activity against the Beta variant.

This study shows NSUN2-mediated m5C methylation of IRF3 mRNA reduces type I interferon responses by promoting IRF3 mRNA degradation, and NSUN2 levels decrease during viral infection to enhance antiviral immunity.

This study investigates SARS-CoV-2 interactions with human macrophages, finding that viral exposure leads to pro-inflammatory cytokine expression and reduced type I interferon activity.

The paper isolates and characterizes a Cyprinid herpesvirus strain YZ01 from goldfish exposed to elevated water temperatures, showing high genomic similarity to other C genotype strains.

ASER compiles sex reversal data from 18 species, including genes, regulatory networks, RNA-seq, and ISH images, to support research on animal breeding and human health.

This study analyzes rhizosphere bacterial diversity of Angelica dahurica var. formosana across different sites and varieties, finding stable communities and key taxa linked to yield and quality.

The paper designs SARS-CoV-2 neutralizing antibodies using a computational platform to improve binding affinity and developability, and introduces trispecific formats and Fc modifications to enhance efficacy and reduce risk.

The paper identifies ELMOD proteins in Arabidopsis that control aperture domain formation on pollen surfaces, showing their roles in regulating aperture number, position, and morphology.

The paper uses live imaging to show that timing of meristem transitions in fern gametophytes affects their morphology.