Z. Chen

This study shows that dimeric IgA antibodies can enhance SARS-CoV-2 nasal infection and injury in Syrian hamsters by engaging CD209 as an alternative receptor.

This paper reports cryo-EM structures of human ABCD1 in different states to elucidate its mechanism of substrate recognition, translocation, and release.

This study shows that Zika virus causes placental pyroptosis via GSDME activation, leading to adverse fetal outcomes.

The paper identifies mosaic evolution in multiple beta-barrel porin genes in E. coli, showing local recombination and sequence variation that may help bacteria evade environmental threats.

This paper develops an in-situ printing system using a human platelet lysate-based bio-adhesive to treat corneal perforations, showing improved adhesion, burst pressure, and faster healing in rabbits compared to cyanoacrylate glue.

This study shows that SARS-CoV-2 ORF7 increases monocyte chemotaxis via CCL2 and decreases neutrophil recruitment via reduced IL-8.

This study identifies α-taxilin and γ-taxilin as new components of centriolar subdistal appendages, showing their role in microtubule anchorage and spindle orientation.

This study analyzes whole-genome sequences of domestic and wild sheep to uncover introgression events and domestication-related genes in European and Asiatic mouflons.

The paper compares vaccine efficacy against Delta and Lambda SARS-CoV-2 variants, finding Lambda has greater escape potential, with reduced antibody reactivity and therapeutic antibody binding.

The paper introduces a universal microfluidic method for studying bacterial biofilms, demonstrating insights into H2O2 resistance and resource retention mechanisms in E. coli and P. aeruginosa biofilms.

The paper establishes a bacterial genome and culture collection of the piglet gut microbiome, revealing new species and functional insights.

The paper identifies Rhodanese 2 (Rdl2) as critical for protecting mitochondria from hydroxyl radical damage in yeast by converting sulfur species into reactive sulfane sulfur.

This study investigates the tissue-specific roles of mitochondrial complex I and IV in adult mouse liver, finding that complex I loss is tolerated while complex IV dysfunction causes metabolic and functional impairments.

NOBIAS analyzes single-molecule tracking data using nonparametric Bayesian inference and deep learning to identify diffusive states, transitions, and anomalous diffusion in live-cell experiments.

This study identifies two antibodies, F61 and H121, that neutralize SARS-CoV-2 and its variants, including B.1.1.7 and B.1.351, by targeting distinct epitopes on the RBD.

ASER compiles sex reversal data from 18 species, including genes, regulatory networks, RNA-seq, and ISH images, to support research on animal breeding and human health.

This study determines the crystal and cryoEM structures of ALC1 and its nucleosome-bound form, revealing the autoinhibition mechanism and activation by the nucleosome.

This study examines right ventricle remodeling in tail-suspended rats under microgravity simulation, finding STAT3 accumulation and gap junction remodeling without significant hypertrophy.

This study develops a versatile linker chemistry for in situ labeling of hydrolase-targeting probes using quinone methide species, showing improved labeling efficiency in living cells.

Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.

This study shows YTHDF2, an m6A reader, enhances NK cell anti-tumor and anti-viral responses by regulating homeostasis, maturation, and effector function through STAT5 feedback and Tardbp interactions.

This study shows that tonic interferon signaling maintains immune homeostasis by regulating gut microbiota, preventing IL-17-driven inflammation and myeloid hyperplasia in STAT1 KO mice.

This study reveals how the kinase fold of SidJ catalyzes protein glutamylation and identifies SdjA as a glutamylase regulating SidE-ligases during Legionella infection.

The paper identifies conserved antigenic sites in SARS-CoV-2 and SARS-CoV RBDs and designs RBD variants to improve immunogenicity for universal vaccine development.

This study identifies RasGRP1 as a bifunctional regulator that promotes acute inflammation and inhibits inflammation-associated cancer growth.

The paper shows that the 501Y.V2 and 501Y.V3 SARS-CoV-2 variants have mutations that reduce binding to the antibody Bamlanivimab.

The paper investigates how EphA2 receptor clustering affects signaling efficiency by using substrates with controlled ligand mobility, finding that clustering increases phosphorylation and binding dwell time for signaling modules.