W. Zhou

This paper predicts atomic-resolution structures of degrader-mediated ternary complexes using combined HDX-MS and molecular dynamics simulations, validated by experimental data.

The paper identifies IAP inhibitors as sensitizers that restore immune response in LKB1-mutant lung cancer by reactivating the STING pathway and enhancing immune infiltration.

The paper uses single-cell CRISPR perturbation to study how transcription factors influence progression speed and trajectory choice in early T-cell development.

This study investigates how excess calories affect lipid droplet structure in adipose tissue, finding that bile acids and tissue-specific factors influence droplet remodeling and adipocyte size.

This study uses iTRAQ-based proteomics to identify cold stress-responsive proteins in japonica rice seedlings, finding 289 regulated proteins involved in photosynthesis and metabolism.

This study modifies the transmembrane helix lengths of TatA and TatB in E. coli to assess the role of hydrophobic mismatch in Tat pathway function, finding that 15 residues are optimal for membrane integrity and transport activity.

The paper describes a workflow for cultivating skin, oral, and gut microbes using metagenomic data and validates its effectiveness.

This study investigates how Trichostatin A (TSA) affects IL-17A-induced transformation of MRC5 cells into myofibroblasts and identifies the TGF-β1/Smads signaling pathway as the mechanism.

Cryo-EM and EPR analysis reveal cooperative substrate binding in BmrCD in an architecture primed for transport.

This study examines gene expression evolution in Trinidadian guppies during parallel adaptation, finding both plasticity and divergence in transcriptional responses across populations.

This study identifies TGF-beta and TSP1 as key drivers of microtube formation in glioblastoma, showing their role in invasion and treatment resistance.

This study uses single-cell RNA sequencing to analyze aging-related changes in subcutaneous adipose tissue, revealing shifts in cellular roles and metabolic phenotypes associated with aging.

This study develops a selective DYRK2 inhibitor, C17, and identifies novel targets like 4E-BP1 and STIM1, revealing DYRK2's role in protein synthesis and calcium entry.

The paper identifies cis-regulatory changes in a gene linked to adaptive radiation in cichlid fishes by showing their impact on gene expression patterns across lineages.

This study shows that bile acid overload in a mouse model impairs brown adipose tissue thermogenic function, with mitochondrial dysfunction and senescence gene induction.

This study compares nitrogen dynamics in maize-soil systems with urea and urea-straw treatments, finding that straw enhances nitrogen availability through rhizosphere interactions.

This study develops a new paralog removal pipeline (PPD) for Hyb-Seq data, showing it resolves conflicts with RAD-seq in phylogenomic analyses of Hamamelis and Castanea.

This study shows that MAPK6 activates AKT to promote cancer, leading to oncogenic outcomes and poor patient survival in multiple cancers.

The paper introduces DNA-origami-based fluorescence brightness standards for fast and convenient protein counting in live cells, compatible with various imaging applications.

This paper develops a deep learning system for gastric cancer detection using histopathological images, achieving high sensitivity and robust performance across different scanners.

This study develops a recombinant SARS-CoV-2 RBD molecule fused with a T helper epitope as an adjuvant, showing strong neutralizing antibody response in mice.

This study shows cancer cells use fructose metabolism to drive the Warburg effect by converting glucose to fructose via polyol pathways and exporting fructose to the tumor microenvironment.

This study shows that seminal plasma exosomes increase human sperm calcium levels via the CatSper channel, improving motility and offering potential clinical applications for asthenozoospermia.

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

The paper identifies allelic differences in terpene synthase genes that contribute to correlated variation in herbivory-induced and floral volatiles in wild tobacco.

The paper identifies an immunosuppression signature (IMS) and shows that its ratio to an IFN-γ signature better predicts anti-PD-1 therapy response in melanoma than existing biomarkers.

This paper introduces a reagentless sensor that detects molecular analytes in biological fluids by measuring directional diffusion of a nanoscale molecular pendulum and electron-transfer kinetics.

The paper develops a sandwich ELISA method using monoclonal antibodies to detect pre-proinsulin in recombinant human insulin production.

This study identifies MeSSII's role in cassava starch biosynthesis by forming protein complexes with other enzymes, affecting amylose and amylopectin synthesis.

This study shows that search results from different databases vary by location and environment, highlighting the need for more consistent search practices in scientific research.