Y. Shi

This study develops murine hepatoblastoma models from HepT1 cells that exhibit high-risk features like vascular invasion, metastasis, and circulating tumor cells.

This paper develops a liver-on-a-chip system combined with machine learning to model drug metabolism and identify excipients that reduce hepatotoxicity in vivo.

This study identifies how coronaviruses like PEDV and SARS-CoV-2 evade antiviral responses by manipulating caspase-1 and inhibiting IFN-I signaling through proteolytic activities.

This paper develops equine polyclonal antibodies that broadly neutralize major SARS-CoV-2 variants, showing high efficacy in vitro and ex vivo with low cost and potential for large-scale production.

This study characterizes the functional domains of Vip3Aa protein from Bacillus thuringiensis and shows how modifying protease sites enhances its insecticidal potency against Spodoptera frugiperda larvae.

This study compares bulk and single-cell mutational analysis to assess tumor clonal structure, finding that bulk analysis underestimates subclonal complexity and dynamic evolution.

This study shows that CMA deficiency in mesenchymal cancers promotes tumor growth via TGFβ signaling and metabolic rewiring.

The paper identifies non-ACE2 blocking neutralizing antibodies in COVID-19 patients using deep RNA sequencing and molecular dynamics simulations, showing their potential for personalized therapy.

This paper introduces a method to improve signal-to-background ratio in 3D-STED nanoscopy using dynamic phase switching with adaptive optics.

This study shows that skeletal muscle is not required for limb regeneration in axolotls, as Pax7 mutants regenerate limbs with normal patterns and cell composition.

This study develops BiTE-sialidase fusion proteins that enhance anti-tumor efficacy by desialylating tumor cells, improving T-cell activation and cytolysis in vitro and in vivo.

The paper identifies Alr3614 as a repressor of type V-K CRISPR-associated transposase systems in Anabaena sp. PCC 7120 through genetic and structural analyses.

The paper reports the chemical structures of two cADPR isomers, their production mechanism, and their roles in antiviral signaling and plant immunity suppression.

This study identifies endothelial SIRPα signaling as critical for thymic progenitor homing, T cell regeneration, and antitumor immunity through CD47-SIRP interactions and VE-cadherin endocytosis.

This study identifies FoxP3-mediated inhibition of RyR2 as a mechanism by which regulatory T cells suppress immune responses through reduced calcium signaling and impaired T cell-DC interactions.

The paper identifies two competing bacterial guilds in the gut microbiome that correlate with host health conditions and can classify multiple diseases across diverse populations.

This study identifies FtMYB102 and FtbHLH4 as a transcriptional complex that promotes rutin accumulation in Tartary buckwheat by inducing CHI expression.

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

This paper develops an ultra-high-throughput method for microbial single-cell whole genome sequencing to study microbial dark matter and improve metagenomic analysis.

The paper investigates reduced antigenicity of the Omicron variant, showing it evades antibodies and lowers serologic response, with implications for vaccine development.

The paper presents near-atomic cryo-EM structures of the Xenopus laevis nuclear pore complex cytoplasmic ring, revealing its scaffold composition and organization.

This study investigates how feed-borne bacteria affect gut microbiota in farmed juvenile Takifugu obscurus, showing that slower growth is linked to greater microbiota instability and increased feed source influence.

This study develops DNA origami nanomedicine to scavenge ROS and NO in M1 macrophages, converting them to M2 subtype and reducing RA inflammation in mice.

This paper introduces a method to efficiently enrich cancer-related exosomes using DNA-tetrahedron nanoweights, achieving high sensitivity and specificity in clinical samples.

The paper isolates and characterizes ultrahigh-affinity nanobodies from a camelid immunized with SARS-CoV-2 RBD, showing broad sarbecovirus neutralization and structural insights.

This study identifies SlBES1.8 as a tomato transcription factor that promotes leaf simplification by modulating gibberellin metabolism and signaling.

This study identifies GRP78 as a positive regulator of HBV enveloped-particle secretion through direct interaction with preS1, suggesting it as a potential therapeutic target.

This study constructs a single-cell transcriptome atlas of multiple myeloma patients stratified by R-ISS, identifies PC subsets and immunotargets, and links them to prognosis and EBV infection.

The paper identifies a chromosomal inversion in walleye fish that may promote adaptive divergence despite gene flow between lakes.

This study identifies a potent human monoclonal antibody, 35B5, that neutralizes SARS-CoV-2 and its variants by targeting a conserved epitope on the RBD, offering a potential therapeutic and vaccine design strategy.