T. Li

TaBln1 negatively regulates wheat resistance to stripe rust by reducing Ca2+ influx through its interaction with TaCaM3 on the plasma membrane.

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

This study shows that knocking out LRIM1 in Anopheles stephensi mosquitoes disrupts microbiome balance, reduces vector competence, and affects reproductive traits.

The paper identifies ICER as a host factor that contributes to HIV resistance in elite controllers by regulating HIV-1 replication through alternative splicing and promoter activity.

This paper demonstrates that annealing the 70S ribosome at a fast cooling rate synchronizes it into a minimum-energy conformation, enhancing homogeneity and stability for structural analysis.

The paper identifies IL20RA as a key factor preventing ovarian cancer metastasis through immune crosstalk with peritoneal mesothelial cells.

This study identifies V-ATPase as a universal regulator of LC3-associated phagocytosis and non-canonical autophagy, showing its role in CASM activation and its disruption by Salmonella SopF.

The paper analyzes immune cell diversity across 15 human tissues using single-cell RNA sequencing and VDJ sequencing, revealing tissue-specific features and clonal architecture of T and B cells.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

The paper develops a spatial genomics method to map cancer clone structure, character, and evolution across breast cancer progression stages.

This study shows rapalogs like rapamycin increase SARS-CoV-2 infection by reducing antiviral proteins through microautophagy, while ridaforolimus has less effect.

The paper investigates how RNA-binding proteins (RBPs) influence RNA polymerase II activity through phase separation, showing that RBPs like PSPC1 enhance polymerase engagement and transcription.

This study examines the kinetic response of B-cell receptor (BCR) repertoire diversity and lineage expansion in non-human primates after TLR7/8 stimulation, finding that TLR7/8 selectively expands high-mutation, low-frequency IgKL lineages.

This paper demonstrates that mass photometry can rapidly and accurately characterize rAAV vectors by resolving capsid populations and quantifying full and empty capsids.

This study shows R13, a TrkB agonist, improves mitochondrial function and reduces AD-related pathology in 5xFAD mice by enhancing biogenesis and metabolism.

This study shows that colonic epithelial cells adapt to EGFR-independent growth, leading to chromosomal instability and accelerated by prior injury, without introducing cancer driver mutations.

This study examines co-infection and secondary infection rates in COVID-19 patients, finding low rates of Streptococcus pneumoniae co-infections and common secondary pathogens like S. maltophilia.

The paper functionally and antigenically characterizes the hemagglutinin and neuraminidase of Wuhan spiny eel influenza virus to assess its status as a bona fide influenza virus.

The paper examines HDP gene expression and tissue distribution in different chicken breeds, finding correlations between body weight, age, and HDP expression in immune organs and intestine.

This paper develops a hybrid alphavirus-SARS-CoV-2 particle for rapid in vitro screening of neutralizing antibodies, viral variants, and antiviral drugs, showing increased infectivity of variants and enhanced neutralization by post-vaccination serum.

The paper quantifies the phase separation properties of chromatin-associated proteins using an anti-1,6-hexanediol index and shows functional correlations with chromatin organization.

This paper introduces a humanized animal model using patient-derived xenografts to study myeloproliferative neoplasms and identify therapeutic vulnerabilities.

This study shows NMNH enhances NAD+ and inhibits glycolysis, TCA cycle, and cell growth, but does not affect mice.

The paper identifies cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 epitope and its variants, showing their ability to activate and kill infected cells.

The paper describes the biosynthesis of new cinnamid and rosmarinic acid-derived compounds in E. coli that inhibit Leishmania amazonensis arginase, with some compounds showing micromolar inhibition.

This study evaluates two adenovirus vectored COVID-19 vaccines in mice and macaques, showing strong immune responses after prime-boost vaccination.

This study shows that deleting Slc26a9 in parietal cells of mice leads to spontaneous gastric cancer and identifies molecular mechanisms involved in tumor progression.

This study shows SARS-CoV-2 and GX_P2V can infect human endoderm, ectoderm, and lung progenitor cells derived from hESCs, with some infections blocked by whey protein and Remdesivir.

This study identifies a high-affinity nanobody that, when fused to other nanobodies, enhances their potency against SARS-CoV-2 by improving RBD binding without disrupting RBM conformation.