T. Li

This study shows that 17-E2 reduces liver fibrosis in male mice by decreasing collagen synthesis and increasing collagen degradation.

This study identifies how Rabphilin 3A binds the N-peptide of SNAP-25 to enhance SNARE complex assembly, facilitating vesicle exocytosis.

This study identifies a necroptosis-related gene signature (NRGscore) to predict prognosis and therapeutic response in bladder cancer patients using TCGA data.

This study determines the structure of NF-κB p52 homodimer-DNA complexes and shows how DNA conformation and binding kinetics influence transcriptional activation.

This paper identifies a potent antibody cocktail that synergistically neutralizes SARS-CoV-2 and its variants, including Omicron BA.1 and BA.2.

This paper develops an ultra-high-throughput method for microbial single-cell whole genome sequencing to study microbial dark matter and improve metagenomic analysis.

This study investigates microbiota dysbiosis and liver metabolomic changes in rats during brain death, finding dysbiosis but no changes in microbial metabolites and significant liver metabolic deterioration.

The paper develops and characterizes monospecific and bispecific monoclonal antibodies that neutralize SARS-CoV-2 and its variants, including B.1.617.2 Delta.

This study develops RAMIHM, a method to generate potent human monoclonal antibodies against SARS-CoV-2 Omicron using mRNA immunization of humanized mice, identifying three highly effective antibodies.

This study identifies HERV activation in BA livers and shows it re-educates macrophages, impairing neutrophil recruitment and causing liver damage, suggesting therapeutic targets.

The paper presents a dataset supporting labyrinthin as a pan-adenocarcinoma marker through topology, homology, and cell surface localization analyses.

This paper introduces microfluidic cantilevers for single-cell mass measurement, achieving sub-nanogram sensitivity and demonstrating improved performance with polymer materials.

This study characterizes the HERV-K (HML-8) group in the human genome, identifying 40 proviruses and 5 solo LTR elements and determining their integration time and genomic distribution.

This study examines eukaryotic plankton community assembly in the northern South China Sea, finding temperature as a major driver and differential roles of deterministic and stochastic processes across plankton size classes.

The paper uses photo-crosslinking and computational docking to determine the in situ cell-surface conformation of the TCR-CD3 complex, revealing a novel arrangement of CD3 subunits around the TCR.

A human antibody, VacW-209, broadly neutralizes SARS-CoV-2 variants including Omicron by targeting a conserved epitope, highlighting the importance of such antibodies in pandemic control.

This study shows that hemagglutinin stability affects influenza A virus susceptibility to Arbidol, with stabilized mutants being more sensitive and destabilized ones more resistant.

This study shows that ALA-PDT kills drug-resistant M. marinum in vitro and in a mouse model, leading to recovery of cutaneous lesions and clinical improvement in two patients.

This study identifies how Omicron evades neutralizing antibodies by analyzing mutations and their effects on different epitope groups, showing over 85% of tested antibodies are escaped.

This study investigates how ubiquitination regulates cytoophidium assembly in Schizosaccharomyces pombe by identifying ubiquitination regulators and deubiquitinating enzymes involved in CTPS filamentation.

This study identifies Nla28 target genes in Myxococcus xanthus during starvation, revealing their roles in spore production and stress resistance.

This study identifies lactoferrin, MUC1, and α-lactalbumin in human breastmilk as antiviral components that inhibit SARS-CoV-2 infection and replication, including variants.

This study identifies Vaccinia E5 as a major inhibitor of the cGAS-STING pathway by promoting cGAS degradation through proteasome-dependent ubiquitination.

This paper introduces a deep learning method for single-frame super-resolution microscopy, enabling live-cell imaging at nanometer-scale spatial and millisecond temporal resolutions.

This paper develops nanocrown electrodes for reliable intracellular recording of cardiomyocytes and demonstrates their use in cardiotoxicity screening.

The paper identifies how EPS1, a BAHD acyltransferase, evolved to catalyze a unique lyase reaction in SA biosynthesis in Brassicaceae plants through active site reconfiguration.

This study identifies 97 chemical constituents of Jing-Fu-Kang granules and reveals 531 common targets and 136 pathways involved in its mechanism for cervical spondylosis using mass spectrometry and network pharmacology.

This study identifies MAFB as a key mediator of GC-induced tolerogenesis in dendritic cells, showing its role in epigenomic and transcriptomic remodeling.

The paper identifies key glucosyltransferase and glucuronosyltransferase enzymes in Scutellaria baicalensis and shows how SbUGAT4 contributes to the high accumulation of baicalin in root tissues.

This study isolates and characterizes two nanobodies against SARS-CoV-2 that neutralize the virus through distinct mechanisms, with one showing efficacy against the Alpha variant and reduced activity against the Beta variant.