W. Zhang

This paper introduces KeyAlloSite, a method to predict key allosteric residues using coevolutionary coupling, showing its accuracy in known proteins and applications in drug design and enzyme engineering.

The paper identifies 4 immunoprognostic genes in ccRCC using bioinformatics analysis of public databases and validates their association with prognosis and immunotherapy response.

This study develops methods to culture planarian neoblasts and deliver exogenous mRNAs, demonstrating retained pluripotency and improved yield.

This study identifies FOXP2 as an oncogene in prostate cancer that activates MET signaling, promoting tumorigenicity through both full-length and truncated forms.

This study investigates microRNA-mediated cross-kingdom regulation between Asian honey bee and microsporidian using RNA-seq and small RNA-seq data, identifying miRNA-target mRNA interactions and their roles in glycolysis, virulence, and immune response.

This study identifies distinct roles for three Mex67 paralogs in trypanosome RNA processing and export, showing non-redundant functions in mRNA export and ribosome biogenesis.

This study shows liver endothelial cells promote PDAC growth via HER3-AKT signaling, suggesting HER3-targeted therapies for HER3-positive metastatic PDAC.

This study shows that the N-termini of lipidated ATG8 proteins associate with membranes in cis, which is essential for autophagosome expansion and efficient p62 degradation.

This study edits two IDA homologues in Brassica napus to prevent petal shedding, enhance silique shattering resistance, and extend flowering period, without affecting agronomic traits.

The paper develops an uncapped mRNA platform and demonstrates its effectiveness in inducing immune responses and protein expression in vitro and in vivo.

The paper identifies enhancer RNAs in oesophageal adenocarcinoma using RNA-seq and open chromatin maps, revealing new deregulated pathways and their clinical relevance.

This paper introduces PathFinder, an interpretable AI framework for discovering new tissue biomarkers in liver cancer, identifying tumor necrosis as a prognostic factor.

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

This study identifies ILC3s as key regulators that promote RORγt+ Tregs and suppress Th17 cells to maintain intestinal tolerance to microbiota.

This study compares antibody neutralization efficacy against SARS-CoV-2 Omicron sub-lineages BA.1, BA.1.1, BA.2, and BA.3, showing increased resistance and the benefit of vaccine boosters.

A comprehensive mutational analysis of the catalytic domain of Arabidopsis CESA6 reveals distinct roles for conserved motifs in CSC vesicle trafficking, protein complex formation, or protein dynamics.

This study identifies climate-driven factors shaping nematode diversity in forest soils across different climatic zones.

This study identifies aberrant DNA methylation patterns in AT/RTs that disrupt neural development and contribute to tumor malignancy.

This study identifies miR-99 and ROR as regulators of neutrophil migration and anti-microbial defense in zebrafish.

This paper describes NBI-921352, a selective NaV1.6 inhibitor that prevents seizures in Scn8a gain-of-function mice and wild-type models, with better efficacy and tolerability than existing antiseizure drugs.

This study shows peramivir reduces cytokine storm by inhibiting NF-κB activity in macrophages and alleviates lung injury in mice.

The paper improves a DNA polymerase's efficiency for unnatural nucleotide incorporation by identifying two key mutations through machine learning and mechanistic analysis.

This study shows that an Omicron-matched DNA vaccine booster enhances cross-reactive immunity against Delta and Omicron variants in mice compared to an ancestral strain booster.

The study compares antigen-antibody interactions at different states using QDB, showing conformational epitopes dominate interactions, challenging Western blot as a validation tool for IHC and ELISA antibodies.

This study identifies structural barriers in resistant tomato roots that restrict Ralstonia solanacearum colonization and slow disease progression.

This study evaluates cause-specific survival in elderly differentiated thyroid cancer patients comparing surgical treatment vs. non-surgical management and the impact of RAI-131 therapy.

This study shows FoxP3 can form two dimerization states, with head-to-head dimerization supporting function and swap-dimerization impairing it.

This study shows that BA.2 causes stronger antibody evasion than BA.1, particularly in SARS convalescents, and identifies key mutations responsible for this escape.

The paper identifies IgD+CD21-CD23- age-associated B cells as precursors of infection-induced B cells in aged mice, which provide protective antibody responses and can be induced by inactivated vaccines.