Y. Sun

This study identifies Rmt5 as a critical regulator of Cryptococcus neoformans morphology and virulence by characterizing its interactome and phenotypic effects.

This study improves CRISPR/Cas9 systems for efficient gene editing in dicot plants, achieving over 80% homozygous/bi-allelic mutations in tobacco and tomato.

This study evaluates the effectiveness of a disinfectant combining highly complexed iodine and compound organic acids in inactivating African swine fever virus under various conditions, showing dose- and time-dependent inactivation with synergistic effects.

This paper demonstrates that non-T-cell based antigen depletion can induce apoptosis in CD19-expressing cancer cells, proposing a universal cellular therapy strategy using artificial antigen-recognizing cells.

The paper identifies a chloroplast envelope domain where translation occurs, supporting co-translational protein targeting in Chlamydomonas reinhardtii.

This study investigates the biogenesis of propanediol-utilization metabolosomes in bacteria, revealing both 'Shell first' and 'Cargo first' assembly pathways.

The paper uses mass spectrometry to determine the absolute stoichiometry of native and recombinant carboxysomes, revealing structural variability and assembly principles.

This study compares alpha-synuclein fibril structures from preclinical and postmortem Parkinson's disease patients, showing structural and pathological differences in fibril conformation during disease progression.

This study shows pVHL regulates TCF/LEF protein stability via ubiquitin-independent proteasomal degradation, revealing a novel mechanism in Wnt/β-catenin signaling.

The paper shows that a myofibrillar matrix is conserved across species and regulated by both cell-type dependent and independent mechanisms in Drosophila muscles.

This study evaluates the effect of Idesia polycarpa fruit residues fermented feed additive on laying quail egg production and related performance metrics, finding improved egg production, reduced cholesterol, and enhanced lipid metabolism.

The paper reports the cryo-EM structure of an amyloid fibril formed by the E196K mutation in human PrP, revealing a distinct conformation compared to wild-type PrP fibrils.

This study shows that removing PU.1 in adipocytes increases energy expenditure and improves metabolic syndrome in aging mice.

This study shows that South American yellow fever virus strains are less susceptible to vaccine-induced antibodies due to genetic changes in the glycoprotein E.

This study shows that transferring gut microbiota from SLE patients to germ-free mice induces lupus-like features, suggesting a causal role for gut microbiota in SLE pathogenesis.

This study identifies 97 chemical constituents of Jing-Fu-Kang granules and reveals 531 common targets and 136 pathways involved in its mechanism for cervical spondylosis using mass spectrometry and network pharmacology.

This study shows that reducing DAF-2 in the intestine of C. elegans nearly doubles lifespan without affecting development or reproduction.

This study uses single-nucleus RNA-seq and spatial transcriptomics to identify lineage-specific regulatory changes and candidate therapeutic targets in hypertrophy cardiomyopathy.

The paper identifies non-reproducible antibody-antigen interactions in clinical sera and develops a model to explain them, improving serological testing for viral infections like COVID-19.

This study shows that strain gradients can drive directional cell migration in rat embryonic fibroblasts, distinct from durotaxis or haptotaxis.

This paper develops an oncolytic viral vector-based vaccine that prevents COVID-19 and treats tumor progression in preclinical models.

This paper develops a deep-learning enhanced on-chip DSLM system for high-speed volumetric imaging of neural activity in moving Drosophila larvae.

This study identifies Rnd3 as a protective factor in placental mitochondria through PPARγ-UCP2 signaling, showing its role in mitigating oxidative stress in preeclampsia.

This paper introduces a multiview super-resolution microscopy approach that enhances confocal microscopy resolution and reduces phototoxicity across multiple scales.

This study introduces a contraction-reaction-diffusion model that generates circular patterns in embryogenesis by coupling mechanobiological factors with traditional reaction-diffusion equations.

This study shows KDM4 promotes epigenomic changes in senescent cells, enhances the SASP, and presents a therapeutic target for age-related diseases.

The paper elucidates the dideoxygenation mechanism in gentamicin biosynthesis, showing how intermediates JI-20A and JI-20B are converted to gentamicin C complex through phosphorylation and PLP-dependent enzymatic reactions.

The paper shows that surface-to-mass coupling determines dry-mass density in Bacillus subtilis by linking envelope synthesis to volume regulation.

This paper develops and characterizes SARS-CoV-2 RBD-specific alpaca nanobodies, showing improved binding affinity and neutralizing potency through bivalent engineering.

This study identifies procyanidin C1 as a natural senolytic agent that selectively kills senescent cells and improves healthspan in aged animals.