Y. Zhao

This study shows that SARS-CoV-2 N protein modulates innate immunity by both suppressing and promoting IFN-I and inflammatory responses depending on its dosage.

This study investigates the neurobehavioral effects of PCB153 exposure in zebrafish, finding delayed startle responses and disrupted dopaminergic and GABAergic signaling.

The paper identifies a chemical inhibitor of the CorC Mg2+ transporter and provides structural insights into its mechanism of action.

This study examines how mutations in the B.1.1.7 variant of SARS-CoV-2 affect neutralization by monoclonal antibodies targeting non-RBD epitopes.

This study compares knowledge and awareness of COVID-19 between Chinese dental students and nonmedical students, finding dental students scored higher overall but had weaknesses in treatment and prevention.

The paper identifies a novel Roseobacter lineage, CHUG, with reduced genomes and vitamin B12 auxotrophy, suggesting a free-living lifestyle and genome reduction driven by relaxed purifying selection.

This study identifies the ZmCd1 gene controlling cadmium accumulation in maize grains and develops molecular markers for breeding low-Cd maize varieties.

This study examines chromatin accessibility in CD4+ T cells from SSc patients on MMF, finding sex and autoantibody-associated epigenetic differences linked to Th2 activation.

This study shows Ythdc1, an m6A reader, regulates LINE1 scaffold function in mouse ESCs, affecting self-renewal and differentiation through chromatin interactions.

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.

This study identifies SARS-CoV-2 spike protein as a direct activator of TLR4 signaling in immune cells, leading to sepsis-related inflammation.

This study develops and tests a recombinant RBD-Fc vaccine against SARS-CoV-2, showing protection in non-human primates and mice.

This study examines how furfural residue amendments affect rhizosphere microbiota diversity and composition in long-term maize monocropping, showing increased beneficial microbes and reduced pathogens.

The paper introduces CentTracker, a machine learning tool for analyzing C. elegans GSC mitosis, showing no distinct mitotic subpopulations and spatial clustering of mitoses.

This study reports lipidomic analysis of six RCA roseobacter isolates, revealing unique phospholipid synthesis and adaptation to phosphorus limitation.

The paper identifies a CD127-expressing monocyte subset, M127, associated with anti-inflammatory properties in inflammatory diseases and correlates its expansion with milder COVID-19 outcomes.

This study examines the effects of rhein on bile acid homeostasis in rats, showing dose-dependent changes in bile acid levels and transporter expression without liver or kidney toxicity.

This study examines how stomatal traits evolve from C3 to C4 photosynthesis in Flaveria species, finding a stepwise change with significant shifts in stomatal density and size.

This paper introduces a dual-stage deep-learning network to enhance 3D fluorescence microscopy resolution and throughput, achieving faster imaging with improved contrast and subcellular detail.

The paper reports the cryo-EM structure of pufferfish TMEM206, revealing its trimeric architecture and chloride ion selectivity, and compares it to sodium channels despite sequence differences.

The paper identifies ARID1A deficiency's role in promoting pancreatic tumorigenesis by reducing KRAS-induced senescence through upregulation of ALDH1A1 in mouse PanIN models.

This study identifies genetic determinants of COVID-19 drug efficacy using genome-wide CRISPR screens, revealing genes involved in drug metabolism and immunosuppressive effects.

This study shows that influenza A virus pre-infection increases SARS-CoV-2 infectivity in multiple cell types and worsens lung damage in mice.

This study isolates and evaluates electroactive endophytic bacteria from plant tissues, identifying strains with potential for microbial fuel cells.

The paper identifies JIB-04 as a broad-spectrum antiviral that inhibits SARS-CoV-2 replication and coronavirus pathogenesis in vitro and in vivo.

The paper identifies an IgMhi developmental trajectory in human B cell maturation that connects T2 progenitors to marginal zone B cells and links its disruption to severe SLE.

This study identifies Avr1d as a Phytophthora sojae effector that inhibits GmPUB13 E3 ligase activity by competing with E2 ubiquitin conjugating enzymes, stabilizing the susceptibility factor and facilitating infection.

This paper introduces a novel bioorthogonal reaction, FTDR, for selectively labeling acetylation substrates using fluorine-thiol displacement, enabling detection and imaging of acetylated proteins.

This paper identifies CR3022 as a monoclonal antibody that neutralizes SARS-CoV-2 by destroying its prefusion Spike conformation, suggesting therapeutic potential.