C. Yang

This study identifies KIM1 as a potential receptor for SARS-CoV-2 in the kidney, showing it binds RBD with similar affinity to ACE2 and facilitates viral entry.

This study identifies exosomal lncRNA PICALM-AU1 from cholangiocytes as a key regulator of endothelial-mesenchymal transition in hepatopulmonary syndrome, with potential as a biomarker and therapeutic target.

This study evaluates two adenovirus vectored COVID-19 vaccines in mice and macaques, showing strong immune responses after prime-boost vaccination.

The paper quantifies bacterial strain engraftment after FMT for rCDI and shows long-term stability in non-relapsing recipients, linking strain presence to clinical outcomes.

This study examines ACE2 and SARS-CoV-2 expression in normal and COVID-19 pancreas tissues, finding prominent ACE2 expression in ductal epithelium and microvasculature, with limited endocrine cell expression and no strong evidence of SARS-CoV-2 infection of endocrine cells.

This study examines the relationship between neuroendocrine and immune gene expression in SCLC, finding that variant SCLC tumors regain immune gene expression and exhibit higher tumor-immune interactions.

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.

This study compares metabolomics profiles in mouse gastric corpus and antrum organoids and tissue, revealing distinct metabolic differences and H. pylori nutrient utilization patterns.

This study shows that activating the UPRmt through ATFS-1 increases mitochondrial import efficiency, preserves import capacity with age, and extends lifespan in worms.

This study shows that beige adipocytes can improve glucose metabolism and energy expenditure in the absence of brown adipose tissue in vivo.

This study identifies integrin β3 as a RACK1-interacting protein essential for PRRSV infection and NF-κB activation in Marc-145 cells, revealing a positive feedback loop involving NF-κB and ITGB3/RACK1.

This study shows that PCH2-mediated dissociation of ASY1's HORMA domain from its closure motif is essential for nuclear targeting and chromosomal loading, while the closure motif is also required for PCH2-mediated removal later in prophase.

The paper identifies the hexosamine biosynthesis pathway as a metabolic vulnerability in KRAS/LKB1 mutant lung cancers and shows GFPT2 inhibition reduces tumor growth.

This paper develops a machine learning pipeline for segmenting subcellular structures from cryo-electron tomograms, using supervised and semi-supervised techniques to improve segmentation accuracy.

This study uses single-molecule detection to show Skp binds OmpC with high affinity, revealing stoichiometry modulation in the complex formation.

This paper identifies lipid imbalances caused by IDH1 mutations that lead to organelle dysfunction, with therapeutic implications for glioma treatment.

This study tracks single melanoma cells' response to BRAF inhibitors and identifies non-genetic mechanisms enabling rapid drug escape within 3 days of treatment.

This paper introduces a bottom-up method for designing functional proteins tailored to complex motifs, demonstrating their use as biosensors and signaling ligands.

This study shows that Nrf2 represses ER stress-related ferroptosis in renal carcinoma cells through the HO-1 pathway, suggesting it as a potential therapeutic target.

This paper introduces a de novo protein design algorithm called TopoBuilder that generates immunogens inducing precise antibody responses against respiratory syncytial virus in mice and non-human primates.

The paper quantifies vertebrate biodiversity in Ailaoshan reserve using leech iDNA, showing species richness increases with elevation and distance from the reserve edge.

This study identifies ZNF704 as a driver of breast carcinogenesis by disrupting circadian rhythms through repression of PER2 and other clock genes.

The paper identifies coadapted genetic elements in Vibrio parahaemolyticus through genome-wide screening, revealing complex interactions and ecological strategies.

The paper introduces a fluorescent reporter to measure cell cycle speed in single cells using one snapshot, demonstrating its application in hematopoietic cells and solid tissues.

The paper identifies Bacteroides ovatus strains that induce IgA production and shows that manipulating these strains can modify gut IgA levels in mice.

This study characterizes the structural and biochemical interactions of the MazEF-mt9 TA system in M. tb, revealing its cognate and heterologous antitoxin binding and its role in stress adaptation.

This study identifies USP7's dual role in stabilizing EZH2 and facilitating PRC2 chromatin loading, promoting melanoma progression and correlating with poor patient prognosis.

The paper develops chromosome-specific KASP assays to rapidly detect and assess homozygosity of wild relative introgressions in wheat.

This study compares human and Naegleria CKK domains to show how structural differences in tubulin conformations enable microtubule minus-end recognition.

The paper quantifies metabolic features in NSCLC cell lines to explore associations between metabolism and other cell-autonomous processes.