L. Chen

This study identifies a conserved interface in KATP channels critical for Mg-ADP activation through mutagenesis experiments and structural analysis.

The paper identifies and characterizes diverse extrachromosomal elements in Methanoperedens archaea, including mini-Borgs and viruses, and shows their genetic exchange and potential impact on archaeal activity.

The paper identifies a novel mechanoadaptive process in intervertebral discs through collagenesis, revealing TRPV4's role in collagen II synthesis and mechanical stress adaptation.

This study identifies distinct roles of MSH2 and MLH1 in basal-like breast cancer, showing MSH2 promotes metastasis while MLH1 enhances it, and reveals MSH2's role in immune modulation through IFNAR1 regulation.

The paper constructs a super-pangenome of 19 Populus species to explore genomic factors driving adaptation and diversification in forest trees.

This study overexpresses SvHXK6 in mesophyll cells of C4 Setaria viridis, improving water use efficiency without reducing biomass or yield.

This study introduces disulfides into SARS-CoV-1 spike protein to stabilize locked conformations, revealing conserved structural features with SARS-CoV-2.

This study characterizes human fetal liver terminal erythropoiesis through RNA sequencing of primary and cultured erythroblasts and immortalized cell lines, revealing gene expression patterns and pathway changes associated with enucleation.

This study shows imidacloprid causes developmental delay in honey bee larvae by disrupting molting regulation and nutrient energy metabolism.

This paper identifies synergistic drug combinations in AML using high-throughput methods and open-source tools, revealing synergies affecting histone H3 lysine-27 modification.

This paper shows that a bispecific antibody targeting PD-L1 and TIGIT enhances T-cell response and tumor control compared to using the individual antibodies.

The paper uses scRNA-seq to analyze signaling between hematopoietic stem/progenitor cells and their niches in AML, identifying inflammatory niche remodeling as a factor affecting tissue failure and patient outcome.

This study shows that ZnF2-defective GATA3 mutations impair LLPS and DNA binding, reducing breast cancer progression and enhancing type I IFN signaling.

The paper discovers a lymphatic bridge connecting Schlemm's canal to limbal and conjunctival lymphatic pathways using advanced imaging techniques in mice.

This study identifies ZBP1-mediated macrophage necroptosis as a mechanism that inhibits ASFV replication by promoting proinflammatory cytokine release.

This study shows that targeting ACOD1 enhances the pro-inflammatory state and anti-tumor activity of human CAR-iMACs in solid tumors.

This paper develops Au-CS@FNDs contact lens additives to block UV, prevent bacterial keratitis, and inhibit corneal neovascularization.

This study evaluates lorlatinib, an ALK inhibitor, in combination with chemotherapy or idasanutlin in preclinical neuroblastoma models, finding synergy in models with high ALK expression.

This study tracks microbial colonization in neonatal calves and identifies genetic links between microbes and host metabolites affecting health and growth.

This study shows that early microbial intervention in newborn calves reduces diarrhea and improves later milk production by altering gut microbiome composition and metabolite profiles.

This study presents haplotype-resolved genomes of triploid bananas, revealing subgenome asymmetric evolution and resistance mechanisms against banana wilt.

This paper reports a method to produce starch efficiently from duckweed under specific conditions and identifies mechanisms behind its high starch accumulation.

This study investigates the reverse evolution of duckweed from land back to water, showing gradual degeneration in root structure, stomatal function, and lignocellulose content, along with gene pathway changes.

This study shows that tolcapone causes embryo lethality and preeclampsia-like phenotypes in mice by inhibiting trophoblast migration and invasion.

This paper introduces Alpha-LFM, a physics-aware deep learning framework for 3D super-resolution imaging of living cells, achieving high resolution, speed, and low phototoxicity over long periods.

The paper shows that m6A and YTHDF2 regulate DUSP1 to enhance innate immune response during infections by promoting DUSP1 degradation and activating MAPKs.

This study creates a spatial transcriptomic atlas of tomato callus during shoot regeneration, identifying cell types and developmental trajectories.

The paper designs and evaluates synthetic isopentyldiol pathways in E. coli, finding that a computationally designed pathway produces IPDO at 2.2 mg/L from glucose.

This study shows that increasing HDAC6 activity impairs mitochondrial complex I in diabetic hearts subjected to ischemia/reperfusion, and that inhibiting HDAC6 improves cardiac function.