Q. Wang

The paper presents a cryo-EM structure of the inner ring subunit from Xenopus laevis NPC, revealing its composition and interactions.

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

This study shows that EBV LMP1 activates mTORC1 and mTORC2 to promote cancer stem cell properties in nasopharyngeal carcinoma, with distinct roles in drug resistance, tumor initiation, and metastasis.

This study uses cryo-EM and simulations to identify four conformational states of the nsp13 helicase in the SARS-CoV-2 RTC, revealing an allosteric mechanism for switching between RNA synthesis and backtracking.

The paper shows that changes in the MPER of HIV-1 Env lead to premature triggering and increased neutralization sensitivity, which can be counteracted by distant State 1-stabilizing Env modifications.

The paper reveals TACAN is a homodimer with lipid-associated domains and suggests membrane lipids coordinate with the protein to sense mechanical signals.

This paper develops a lung-selective Cas13d-based nanotherapy targeting Ctsl to inhibit SARS-CoV-2 infection, showing improved survival and reduced viral burden in mice.

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

This study shows SMC1A promotes gastric cancer progression by enhancing SNAI2-driven EMT, suggesting it as a therapeutic target.

The paper reports the cryo-EM structure of an amyloid fibril formed by the E196K mutation in human PrP, revealing a distinct conformation compared to wild-type PrP fibrils.

The paper shows that inhibiting DPP9 with Val-boroPro enhances NNRTI-induced killing of HIV-1-infected cells by sensitizing the CARD8 inflammasome.

This study presents a chromosome-scale spinach reference genome and resequences 305 accessions to explore evolution, domestication, and genetic basis of agronomic traits.

This study identifies SIGNR1's role in promoting immune dysfunction during systemic candidiasis by modulating neutrophil lifespan through T cell-derived histones and G-CSF.

This study identifies three conserved hydrophobic residues in the CC domain of rice NLR Pit that contribute to plasma membrane localization and immune induction, distinct from their roles in other NLRs.

This study shows GC-derived exosomes induce EMT in peritoneal mesothelial cells via TGF-β1/Smads pathway, enhancing GC cell migration and adhesion.

The paper identifies Rhodanese 2 (Rdl2) as critical for protecting mitochondria from hydroxyl radical damage in yeast by converting sulfur species into reactive sulfane sulfur.

This study evaluates the neutralizing activity of ZF2001 vaccine-elicited antisera against SARS-CoV-2 variants, finding that E484K/Q mutations reduce neutralization and that extended intervals between doses improve variant resilience.

This paper introduces a CRISPR-nCas3 system for efficient genome editing in bacteria, enabling high-efficiency deletion of large genomic regions.

This study identifies a novel AUTS2-containing complex that inhibits BMP signaling to promote neuronal differentiation and reveals its role in neuronal lineage specification.

The paper reports the structures of M. tuberculosis cytochrome bcc complexed with two anti-TB drugs, revealing binding sites and interactions that inform inhibitor design.

ABEL-FRET provides an immobilization-free smFRET platform with Angstrom-level resolution and integrates hydrodynamic profiling for enhanced FRET sensing.

This study identifies two molecular subtypes of gastric cancer using multi-omics data and clustering algorithms, showing distinct survival outcomes and therapeutic responses.

The paper shows radiation induces vascular-like phenotypes in glioma stem cells, creating a trophic niche that promotes tumor recurrence, and identifies P300 inhibition as a potential therapeutic strategy.

This study identifies a novel constitutive MLS resistance in S. haemolyticus and shows that ErmC deletion causes resistance while continuous ErmC expression imposes a growth cost.

The paper introduces a method to determine DNA-protein binding states using diffusivity contrast and validates it with PIFE, enabling simultaneous mapping of stoichiometry and binding location.

This study evaluates a modified B.1.351 spike trimer vaccine candidate, showing it induces broad neutralization against multiple SARS-CoV-2 variants in mice.

This study identifies AK-778-XXMU as a potent ID2 antagonist with potential as a glioma therapeutic through pharmacophore-based virtual screening and experimental validation.

WRKY33 regulates indole glucosinolate biosynthesis and hydrolysis, enhancing resistance to Alternaria brassicicola in Arabidopsis and Brassica crops.

This study identifies ZmLBD5 and ZmLBD33 as class II LBD genes in maize that regulate gibberellin and abscisic acid biosynthesis, affecting plant growth and drought tolerance.

This study identifies unbalanced dietary patterns as contributors to precocious puberty by altering gut microbiota and host metabolites, with biomarkers showing high diagnostic accuracy.