Q. Wang

This study develops polypeptide-based inhibitors that target conserved regions of viral glycoproteins, effectively reducing expression across multiple virus strains with low sequence identity.

This study examines how Saccharina japonica and Sargassum horneri respond to ocean acidification and eutrophication, finding that S. horneri has competitive advantages under combined stress.

This paper shows that SARS-CoV-2 RdRp undergoes backtracking, which may aid proofreading and antiviral resistance.

The paper designs chimeric antisense oligonucleotides that degrade SARS-CoV-2 RNA via RNase L activation, showing twice the efficiency of classic antisense oligonucleotides and broad-spectrum antiviral activity.

This study evaluates S-Trimer, a subunit vaccine candidate for COVID-19, showing it induces protective immunity in nonhuman primates with adjuvants.

This study shows that ferulic acid rescues radiation-induced impairments in skeletal stem cells, enhancing bone repair in irradiated defects through MAPK pathway activation.

This study evaluates enzalutamide's antiviral efficacy against SARS-CoV-2 in different cell types and mouse models, finding it effective in prostate cancer cells but not in lung cells or organoids.

This study evaluates a recombinant chimpanzee adenovirus vaccine expressing a dimeric tandem-repeat RBD of SARS-CoV-2, showing enhanced immune responses and protection in mice.

This study identifies exosomal miR-130a-3p from acinar cells as a regulator of pancreatic fibrosis by targeting PPAR-γ in stellate cells, showing its role in collagen formation and fibrosis progression.

This study identifies SlBES1 as a regulator of tomato fruit softening by repressing PMEU1, leading to firmer fruits with extended shelf life without affecting visual or nutritional quality.

This study tracks the global spread of the carbapenem resistance gene blaNDM by analyzing genomic contexts and mobile genetic elements across 6000 bacterial genomes.

This study reveals how DPP9 regulates CARD8 by forming a ternary complex and shows that DPP9 inhibitors activate CARD8 inflammasomes through two distinct mechanisms.

This study shows that combining glucose metabolism inhibition with MEK inhibition enhances apoptosis in pancreatic cancer cells by inducing ER stress.

This paper introduces a novel EGFR-TKI, CM93, which shows improved brain penetration and efficacy against EGFR-mutated glioblastoma in vitro and in vivo.

This study shows Hsp70 chaperones TDP-43 in liquid-like phase, preventing its aggregation and maintaining dynamic nuclear bodies under stress.

This paper introduces an L1H-CS based SRUS imaging technique that improves image quality and reduces acquisition time for visualizing microvasculature in vivo.

This study shows Ox-LDL, not AngII, induces LOX-1 and AT1-R interaction, leading to cardiomyocyte hypertrophy via Gq protein activation.

This study shows GSTZ1 enhances sorafenib-induced ferroptosis in HCC by inhibiting the NRF2/GPX4 axis, and its deficiency leads to resistance to sorafenib.

The paper develops a method to trace the geographic origin of quarantine insects using their gut microbiota, finding that microbiota diversity and composition correlate with geographic and environmental factors.

This study shows ORMDL1 is upregulated in colorectal cancer and associated with better patient survival.

This paper develops data-informed strategies to design hydrolytic nanozymes with enhanced catalytic activity and broad substrate specificity.

This study identifies abundant and diverse circRNAs from SARS-CoV-2, SARS-CoV, and MERS-CoV, revealing a novel type of circRNA distinct from DNA-encoded circRNAs.

This study shows that calorie restriction affects gut microbiome, which in turn influences metabolism, hormones, and brain function in obese individuals.

This study examines how different light spectra affect nitrogen assimilation and content in Quercus variabilis seedlings under nitrogen pulses.

This study uses micro-XRF to analyze the holotype of Jianianhualong tengi, revealing elemental patterns linked to fossil structure and taphonomy.

This paper demonstrates that hydrogel-coating enhances the in vivo stability of electrochemical aptamer-based biosensors without compromising detection performance.

This paper reports a monoclonal antibody, 3E8, that blocks multiple coronaviruses by targeting ACE2, showing broad-spectrum activity against SARS-CoV-2 variants and other coronaviruses.

This study identifies LsAP2 as a transcription factor regulating seed shape in lettuce, showing its role in seed development and dispersal through interactions with LsBP and involvement in brassinosteroid pathways.